In 2017, Savage toured with Michael Stevens on the Brain Candy LIVE! tour. In April 2017, Savage played the role of a mission specialist in episode Caliban's War of the series The Expanse. In June 2017 Savage was named Humanist of the Year by the American Humanist Association at their annual Conference. October 2017, Savage played a cameo as a merchant selling blood bags in the Blade Runner 2049 short film prequel, 2048: Nowhere to Run. In April 2018, Discovery announced that Savage will host and produce a new series called MythBusters Jr, a series focused on a group of young scientists tasked with completing various experiments of challenges through the use of STEAM skills. In July 2018, Savage in a collaboration with Weta Workshop created and acted in the shortfilm A Farewell To Arms. On February 20th, 2020 Adam Savage was appointed the Creative Director of SiliCon (formally Silicon Valley Comic Con), succeeding Steve Wozniak.
Savage's role with his co-hosts is to disprove or confirm myths through testing and experiments done at different scales. His demeanour on MythBusters is animated and energetic, providing a foil to Jamie Hyneman's more reserved straight-man persona. Savage and Hyneman were the sole hosts of the show for the first season of MythBusters. They introduced members of Hyneman's staff in the second season who began to appear regularly; Kari Byron, Tory Belleci, and welder Scottie Chapman appeared in the second season. In the third season, Chapman was replaced by Grant Imahara, a robot builder and model maker. Filmed in San Francisco and edited in Artarmon, New South Wales, Australia, MythBusters aired 282 total episodes before its cancellation at the end of its 2016 season in March. Savage expressed an interest in proving natural selection over creationism on MythBusters. However, he conceded that such an episode is unlikely because MythBusters has a policy against trying to disprove supernatural phenomena. On November 15, 2017, sister network Science Channel revived the series with the new hosts Jon Lung and Brian Louden, who were selected via the competition spin-off MythBusters: The Search. It is now filmed in Santa Clarita and on location in other parts of southern California.