Discovered by modeling agency King George Models, she was encouraged to pursue acting. She began her career in modeling and appeared in commercials for companies such as Coca-Cola, Nixoderm and Liberia GSM. She ventured into television, where she played mainly minor roles. In 2004, she made her major film debut as Susan in the Obi Obinali directed film Dangerous Sisters. Her other roles include Nneoma, a village girl in End of the game and Jezebel in Dwelling in Darkness and Sorrow.

In 2005, she joined her husband in the United States with whom she had two children. After 2 years living there together, the couple separated. Mazagwu has also starred in films such as Destructive Instinct, How Did I Get Here, Ordeal in Paradise, The Goose That Lays The Golden Eggs and has played small roles in various Hollywood movies. As a musical artist, her first single “Somebody Help Me” was released in 2009 followed by her debut studio album which produced the popular hit “Ikebe Na Moni”. Also in 2011, she released the single “Voodoo-Juju Woman”.