López’s professional career began in 1924 when, at the age of 16, he signed on as a catcher with the Class-D Tampa Smokers of the Florida State League, quitting his job at the bakery and dropping out of high school at Sacred Heart College (later known as Jesuit High School) to focus on baseball. His starting salary with the Smokers was $150 ($2,238 today) per month, which was much needed by the large Lopez family since his father’s health was deteriorating and he could not work regularly. (Modesto Lopez died of throat cancer in 1926.)

Soon after signing with the Smokers, Al López impressed Hall of Fame pitcher Walter Johnson with his catching skills during a winter barnstorming exhibition game. At Johnson’s recommendation, Al was hired as a practice catcher for the Washington Senators during spring training in 1925, a valuable learning opportunity that he later credited with making him a better ballplayer. The Senators offered the Smokers $1000 for López’s contract, but the minor league club demanded $10,000, which the major league club thought too exorbitant for a young player with only one year of professional baseball experience. Instead, López moved steadily up the minor leagues ranks in subsequent seasons and made his major league debut in 1928 with Brooklyn.

After splitting time between the major and minor leagues for two seasons, López became the Dodgers’ primary catcher in 1930 at the age of 21, and he remained a regular starter in the major leagues over the next 17 seasons. His best offensive campaign came in 1933, when he hit .301, stole 10 bases, and finished 10th in National League MVP voting. Overall, he compiled modest career batting numbers, including 613 runs, 51 home runs, and 652 RBIs and a .261 batting average. He was better known for his defense, leadership, and his ability to work with various pitchers, which earned him two trips to the All-Star game and respect around the league.

Al López met Evelyn “Connie” Kearney, a dancer at the Hollywood Club in New York, while he was playing for Brooklyn in the early 1930s, and the couple often went on double dates with teammate Tony Cuccinello and his wife. When López was traded to Boston in 1935, he and Connie found it difficult to conduct a long-distance relationship, so she soon joined him. They married on October 7, 1939 and had a son, Al Jr., in 1940.

Over a major league playing career which ran from 1928 until 1947, López played for the Brooklyn Robins / Dodgers (1928, 1930-1935), Boston Bees (1936-1940), Pittsburgh Pirates (1940-1946) and Cleveland Indians (1947). In 1945, López surpassed Gabby Hartnett’s major league record for career games as a catcher, and when he retired after the 1947 season, his major league record for games caught stood at 1,918. This record was not broken until 1987 by Bob Boone, and the National League record was broken by Gary Carter in 1990. He caught 117 shutouts during his career, ranking him 13th all-time among major league catchers.

After having declined an opportunity to become the club’s manager in 1947, López accepted an offer to become the Cleveland Indians’s new manager in 1951. Under López, the Indians won over 90 games each season from 1951 to 1953, but came in second to the New York Yankees each year. In 1954, Lopez’s squad won a then-American League record 111 games to capture the AL pennant, but were swept by Willie Mays and the New York Giants in the 1954 World Series in one of the biggest upsets in World Series history. Lopez’s Indians again finished in second place behind the Yankees in 1955 and 1956. During the latter season, López became “incensed” at Cleveland fans and management as the season progressed. Star third baseman Al Rosen slumped late in the year while playing injured, and López felt that the Indians’ team management had not supported or defended his injured player from fans’ booing and criticism. López was so disheartened over the situation that he resigned from the club on the last day of the season. Lopez finished his Indians career with a record of 570 wins and 354 losses, and his .617 winning percentage is still the best in franchise history.

Meanwhile, López began his managing career in 1948 with the Indianapolis Indians, the Pittsburgh Pirates’s Class AAA minor league affiliate. He spent three years in Indianapolis, leading his squads to one first place and two second-place finishes in the American Association while also serving as the team’s reserve catcher. Before the 1950 season, López re-signed with the Indianapolis Indians for the largest salary of any manager in American Association history, with a clause in his contract which allowed for him to leave if offered a managerial position with a major league club.

In 1957, his first year in Chicago, López’s White Sox won 90 games and finished in second place behind the Yankees while the Indians suffered through a losing season. Chicago again finished second in 1958, but finally broke through and won the American League pennant in 1959, losing to the Los Angeles Dodgers in the World Series. By this time, Lopez was very well respected and in-demand manager, and in the middle of the 1960 season, a friend of New York Yankees president Dan Topping told an Associated Press reporter that López would replace Yankees manager Casey Stengel. (Stengel had managed López years earlier when López was a catcher for Brooklyn and Boston.) Despite rumored and confirmed inquiries from other teams, López stayed with Chicago until 1965, finishing in second place five times and never posting fewer than 82 wins.

Lopez was the manager of the Cleveland Indians and had just led them to the World Series when the city of Tampa built a new minor league and spring training ballpark. It was named Al López Field, and the date of the dedication ceremony (October 6, 1954) was declared “Al López Day” in the city of Tampa. The Chicago White Sox were the ballpark’s first spring training tenants, and when Lopez became the new White Sox manager in 1957, he had the unusual honor for several seasons of managing home games in his hometown in a ballpark named after himself. Later in life, López would recall a spring training incident in which an umpire with whom he was arguing threatened to throw him out of a game there. “You can’t throw me out of this ballpark”, protested Lopez, “This is my ballpark – Al López Field!” The umpire ejected him anyway, causing Lopez to exclaim, “He threw me out of my own ballpark!”

López retired to the White Sox front office after the 1965 season due to a chronic stomach condition and assumed the title of team vice president. He returned to managing in July 1968, when White Sox manager Eddie Stanky was fired. Lopez was able to get most of his former coaches to return to the team. However, he had to undergo an appendectomy shortly after taking over as manager and missed most of the rest of the season. He agreed to manage the White Sox again in 1969, but continuing health issues forced him to resign in early May, less than a month into the season.

Al and Connie López retired to his hometown in 1970 to live near family and friends. López was the first Tampa native to play in the major leagues, the first to manage a major league team, the first to manage his team to a World Series (Lou Piniella and Tony La Russa each did so later), and the first to be inducted into the Baseball Hall of Fame. As such, he was the recipient of many honors in his hometown, both during and after his long baseball career.

Connie López had died in September 1983. Al López was survived by his son, three grandchildren, and nine great-grandchildren.

Al López Field was demolished in 1989 to make room for a potential major league facility that was never built. López lived a few miles from the ballpark that bore his name. In a 1992 interview, he said that the razing of the stadium “wasn’t very disappointing. I saw a diagram of the new stadium, and I didn’t feel bad because I thought they were going to build a bigger one and a better one. After that, something happened, and they never built the ballpark. Then it was a disappointment.” Soon thereafter, the city of Tampa changed the name of Horizon Park, a large city park near the site of the razed stadium, to Al López Park, and installed a large statue of López in his catching gear. The statue was dedicated on October 3, 1992, a date which was officially proclaimed as a second “Al López Day” in the city. Soon thereafter, his high school, Jesuit High School, which is located across the street from Al López Park, named its new athletic center in Lopez’s honor.

López was selected for induction into the Baseball Hall of Fame by the Veterans Committee as part of the Class of 1977. He served as the AL’s honorary team captain in the 1990 Major League Baseball All-Star Game.

When the expansion Tampa Bay Devil Rays began play in 1998 in nearby St. Petersburg, Lopez threw one of several ceremonial first pitches along with fellow Hall of Famers Ted Williams, Stan Musial, and Monte Irvin. The Rays annually award the “Al López Award” to the “most outstanding rookie” in the team’s spring camp each year.

Al López died on October 30, 2005 at the age of 97 after suffering a heart attack at his son’s home. His death came four days after the White Sox won the 2005 World Series, their first world championship in 88 years and their first AL pennant since Lopez had led them to the World Series in 1959. Lopez was the last living person who had played major league baseball during the 1920s, and was the longest-lived member of the Baseball Hall of Fame until Bobby Doerr passed him in 2015.

In 2013, López’s boyhood home was moved to a lot across the street from the Ybor City State Museum, where it is undergoing renovation to become the “Tampa Baseball Museum at the Al López House”.