In his first novel, Essays in Love (titled On Love in the U.S.), published in 1993, de Botton deals with the process of falling in and out of love. In 2010, Essays in Love was adapted to film by director Julian Kemp for the romantic comedy My Last Five Girlfriends. De Botton wrote a sequel to Essays in Love, published in 2016, titled The Course of Love.

In 1997 he published his first non-fiction book, How Proust Can Change Your Life, based on the life and works of Marcel Proust. It was a bestseller in both the US and UK.

De Botton was born in Zürich, the son of Jacqueline (née Burgauer) and Gilbert de Botton, who was born in Alexandria, Egypt, and expelled under Nasser. Gilbert went to live and work in Switzerland, where he co-founded an investment firm, Global Asset Management; his family was estimated to have been worth £234 million in 1999. Alain de Botton’s Swiss-born mother was Ashkenazi, and his father was from a Sephardic Jewish family from the town of Boton in Castile and León.

This was followed by The Consolations of Philosophy in 2000. The title of the book is a reference to Boethius’s Consolation of Philosophy, in which philosophy appears as an allegorical figure to Boethius to console him in the period leading up to his impending execution. In The Consolations of Philosophy, de Botton attempts to demonstrate how the teachings of philosophers such as Epicurus, Montaigne, Nietzsche, Schopenhauer, Seneca, and Socrates can be applied to modern everyday woes. The book has been both praised and criticized for its therapeutic approach to philosophy.

In 2008, Alain de Botton was one of a team of writers and educators who founded The School of Life. Based in London, Paris, Amsterdam, Antwerp, Seoul, Istanbul, Tel Aviv, São Paulo, Berlin and Melbourne, The School of Life offers an emotional education focusing in particular on the issues of Work and Relationships. In an interview with Metkere.com de Botton said:

In August 2009, de Botton applied to a competition advertised among British literary agents by BAA, the airport management company, for the post of “writer-in-residence” at Heathrow Airport. The post involved being seated at a desk in Terminal 5, and writing about the comings and goings of passengers over a week. De Botton was duly appointed to the position. The result was the book, A Week at the Airport, published by Profile Books in September 2009. The book features photographs by the documentary photographer Richard Baker, with whom de Botton also worked on The Pleasures and Sorrows of Work.

In May 2009, de Botton launched a project called “Living Architecture”–which builds holiday rental houses in the UK using leading contemporary architects. These include Peter Zumthor, MVRDV, JVA, NORD and Michael and Patti Hopkins. The most recent house to be announced is a collaboration between the Turner-prize winning artist Grayson Perry, and the architecture firm FAT. The houses are rented out to the general public. De Botton, the creative director and chairman of Living Architecture, aims to improve the appreciation of good contemporary architecture–a task which is the practical continuation of his theoretical work on architecture in his book The Architecture of Happiness. In October 2009, he was appointed an honorary fellow of the Royal Institute of British Architects (RIBA), in recognition of his services to architecture.

De Botton travels extensively to lecture. He has given lectures at TED conferences. In July 2011, he spoke in Edinburgh about “Atheism 2.0”, an idea of atheism that also incorporates our human need for connection, ritual and transcendence. In July 2009, he spoke at Oxford University about the philosophy of failure and success, and questions the assumptions underlying these two judgments.

In 2011 he presented a series of talks for the BBC Radio 4 series A Point of View.

In January 2012, de Botton published Religion for Atheists, about the benefits of religions for those who do not believe in them. De Botton put it: “It’s clear to me that religions are in the end too complex, interesting and on occasion wise to be abandoned simply to those who believe in them”. In April 2012, he published How to Think More about Sex, one in a series of six books on topics of emotional life published by his enterprise, The School of Life.

In October 2013, he published Art as Therapy, co-written with the Australian-Scottish art historian, John Armstrong. Art as Therapy argues that certain great works of art “offer clues on managing the tensions and confusions of everyday life”.

In February 2014, de Botton published his fourteenth book, a title called “The News: A User’s Manual”, a study of the effects of the news on modern mentality, viewed through the prism of 25 news stories, culled from a variety of sources, which de Botton analyses in detail. The book delved with more rigour into de Botton’s analyses of the modern media which appeared in Status Anxiety.

In 2014, de Botton was invited by three museums–the Rijksmuseum in Amsterdam, the National Gallery of Victoria in Melbourne and the Art Gallery of Ontario in Toronto–to contribute content to special exhibitions based on his work, Art as Therapy. De Botton and his colleague John Armstrong inserted captions, arranged on large Post-it-style labels designed by the Dutch graphic artist, Irma Boom, bearing slogans and commentary on exhibits throughout the Rijksmuseum.

In August 2014, de Botton was one of 200 public figures who were signatories to a letter to The Guardian opposing Scottish independence in the run-up to September’s referendum on that issue.