Huxley was born in Godalming, Surrey, England, in 1894. He was the third son of the writer and schoolmaster Leonard Huxley, who edited Cornhill Magazine, and his first wife, Julia Arnold, who founded Prior’s Field School. Julia was the niece of poet and critic Matthew Arnold and the sister of Mrs. Humphry Ward. Julia named him Aldous after a character in one of her sister’s novels. Aldous was the grandson of Thomas Henry Huxley, the zoologist, agnostic, and controversialist (“Darwin’s Bulldog”). His brother Julian Huxley and half-brother Andrew Huxley also became outstanding biologists. Aldous had another brother, Noel Trevenen Huxley (1889–1914), who took his own life after a period of clinical depression.

Huxley’s education began in his father’s well-equipped botanical laboratory, after which he enrolled at Hillside School near Godalming. He was taught there by his own mother for several years until she became terminally ill. After Hillside he went on to Eton College. His mother died in 1908, when he was 14 (his father later remarried). He contracted the eye disease Keratitis punctata in 1911; this “left [him] practically blind for two to three years.” This “ended his early dreams of becoming a doctor.” In October 1913, Huxley entered Balliol College, Oxford, where he studied English literature. He volunteered for the British Army in January 1916, for the Great War; however, he was rejected on health grounds, being half-blind in one eye. His eyesight later partly recovered. He edited Oxford Poetry in 1916, and in June of that year graduated BA with first class honours. His brother Julian wrote:

During the First World War, Huxley spent much of his time at Garsington Manor near Oxford, home of Lady Ottoline Morrell, working as a farm labourer. There he met several Bloomsbury Group figures, including Bertrand Russell, Alfred North Whitehead, and Clive Bell. Later, in Crome Yellow (1921) he caricatured the Garsington lifestyle. Jobs were very scarce, but in 1919 John Middleton Murry was reorganising the Athenaeum and invited Huxley to join the staff. He accepted immediately, and quickly married the Belgian refugee Maria Nys, also at Garsington. They lived with their young son in Italy part of the time during the 1920s, where Huxley would visit his friend D. H. Lawrence. Following Lawrence’s death in 1930, Huxley edited Lawrence’s letters (1932).

Huxley married Maria Nys (10 September 1899 – 12 February 1955), a Belgian he met at Garsington, Oxfordshire, in 1919. They had one child, Matthew Huxley (19 April 1920 – 10 February 2005), who had a career as an author, anthropologist, and prominent epidemiologist. In 1955, Maria Huxley died of cancer.

In 1937 Huxley moved to Hollywood with his wife Maria, son Matthew Huxley, and friend Gerald Heard. He lived in the U.S., mainly in southern California, until his death, and also for a time in Taos, New Mexico, where he wrote Ends and Means (published in 1937). The book contains tracts on war, religion, nationalism and ethics.

Heard introduced Huxley to Vedanta (Upanishad-centered philosophy), meditation, and vegetarianism through the principle of ahimsa. In 1938, Huxley befriended Jiddu Krishnamurti, whose teachings he greatly admired. Huxley and Krishnamurti entered into an enduring exchange (sometimes edging on debate) over many years, with Krishnamurti representing the more rarefied, detached, ivory-tower perspective and Huxley, with his pragmatic concerns, the more socially and historically informed position. Huxley provided an introduction to Krishnamurti’s quintessential statement, The First and Last Freedom (1954).

Beginning in 1939 and continuing until his death in 1963, Huxley had an extensive association with the Vedanta Society of Southern California, founded and headed by Swami Prabhavananda. Together with Gerald Heard, Christopher Isherwood and other followers, he was initiated by the Swami and was taught meditation and spiritual practices.

Differing accounts exist about the details of the quality of Huxley’s eyesight at specific points in his life. Circa 1939, Huxley encountered the Bates method, in which he was instructed by Margaret Darst Corbett. In 1940, Huxley relocated from Hollywood to a 40-acre (16 ha) ranchito in the high desert hamlet of Llano, California, in northern Los Angeles County. Huxley then said that his sight improved dramatically with the Bates Method and the extreme and pure natural lighting of the southwestern American desert. He reported that, for the first time in more than 25 years, he was able to read without glasses and without strain. He even tried driving a car along the dirt road beside the ranch. He wrote a book about his experiences with the Bates Method, The Art of Seeing, which was published in 1942 (U.S.), 1943 (UK). The book contained some generally disputed theories, and its publication created a growing degree of popular controversy about Huxley’s eyesight.

From 1941 until 1960, Huxley contributed 48 articles to Vedanta and the West, published by the society. He also served on the editorial board with Isherwood, Heard, and playwright John Van Druten from 1951 through 1962.

In 1944, Huxley wrote the introduction to the “Bhagavad Gita: The Song of God”, translated by Swami Prabhavananda and Christopher Isherwood, which was published by the Vedanta Society of Southern California.

On 21 October 1949, Huxley wrote to George Orwell, author of Nineteen Eighty-Four, congratulating him on “how fine and how profoundly important the book is.” In his letter to Orwell, he predicted:

It was, and is, widely believed that Huxley was nearly blind since the illness in his teens, despite the partial recovery that had enabled him to study at Oxford. For example, some ten years after publication of The Art of Seeing, in 1952, Bennett Cerf was present when Huxley spoke at a Hollywood banquet, wearing no glasses and apparently reading his paper from the lectern without difficulty: “Then suddenly he faltered—and the disturbing truth became obvious. He wasn’t reading his address at all. He had learned it by heart. To refresh his memory he brought the paper closer and closer to his eyes. When it was only an inch or so away he still couldn’t read it, and had to fish for a magnifying glass in his pocket to make the typing visible to him. It was an agonising moment”.

In 1953, Huxley and Maria applied for United States citizenship and presented themselves for examination. When Huxley refused to bear arms for the U.S. and would not state that his objections were based on religious ideals, the only excuse allowed under the McCarran Act, the judge had to adjourn the proceedings. He withdrew his application. Nevertheless, he remained in the U.S. In 1959 Huxley turned down an offer of a Knight Bachelor by the Macmillan government without putting forward a reason; his brother Julian had been knighted in 1958, while another brother Andrew would be knighted in 1974.

In 1956, Huxley married Laura Archera (1911–2007), also an author, as well as a violinist and psychotherapist. She wrote This Timeless Moment, a biography of Huxley. She told the story of their marriage through Mary Ann Braubach’s 2010 documentary, Huxley on Huxley.

Huxley had deeply felt apprehensions about the future the developed world might make for itself. From these, he made some warnings in his writings and talks. In a 1958 televised interview conducted by journalist Mike Wallace, Huxley outlined several major concerns: the difficulties and dangers of world overpopulation; the tendency towards distinctly hierarchical social organisation; the crucial importance of evaluating the use of technology in mass societies susceptible to persuasion; the tendency to promote modern politicians to a naive public as well-marketed commodities.

Huxley was diagnosed with laryngeal cancer in 1960; in the years that followed, with his health deteriorating, he wrote the Utopian novel Island, and gave lectures on “Human Potentialities” both at the UCSF Medical Center and at the Esalen Institute. These lectures were fundamental to the beginning of the Human Potential Movement.

On 9 April 1962, Huxley was informed he was elected Companion of Literature by the Royal Society of Literature, the senior literary organisation in Britain, and he accepted the title via letter on 28 April 1962. The correspondence between Huxley and the society is kept at the Cambridge University Library. The society invited Huxley to appear at a banquet and give a lecture at Somerset House, London, in June 1963. Huxley wrote a draft of the speech he intended to give at the society; however, his deteriorating health meant he was not able to attend.

On his deathbed, unable to speak owing to advanced laryngeal cancer, Huxley made a written request to his wife Laura for “LSD, 100 µg, intramuscular.” According to her account of his death in This Timeless Moment, she obliged with an injection at 11:20 a.m. and a second dose an hour later; Huxley died aged 69, at 5:20 p.m. (Los Angeles time), on 22 November 1963.

Huxley’s memorial service took place in London in December 1963; it was led by his elder brother Julian. On 27 October 1971, his ashes were interred in the family grave at the Watts Cemetery, home of the Watts Mortuary Chapel in Compton, Guildford, Surrey, England.

Huxley had been a long-time friend of Russian composer Igor Stravinsky, who later dedicated his last orchestral composition to Huxley. Stravinsky began Variations in Santa Fé, New Mexico, in July 1963, and completed the composition in Hollywood on 28 October 1964. It was first performed in Chicago on 17 April 1965, by the Chicago Symphony Orchestra, conducted by Robert Craft.

During this period, Huxley earned a substantial income as a Hollywood screenwriter; Christopher Isherwood, in his autobiography My Guru and His Disciple, states that Huxley earned more than $3,000 per week (approximately $50,000 in 2020 dollars) as a screenwriter, and that he used much of it to transport Jewish and left-wing writer and artist refugees from Hitler’s Germany to the US. In March 1938, Huxley’s friend Anita Loos, a novelist and screenwriter, put him in touch with Metro-Goldwyn-Mayer (MGM), which hired him for Madame Curie which was originally to star Greta Garbo and be directed by George Cukor. (Eventually, the film was completed by MGM in 1943 with a different director and cast.) Huxley received screen credit for Pride and Prejudice (1940) and was paid for his work on a number of other films, including Jane Eyre (1944). He was commissioned by Walt Disney in 1945 to write a script based on Alice’s Adventures in Wonderland and the biography of the story’s author, Lewis Carroll. The script was not used, however.