Born to Jewish-Ukrainian parents in Chile, Jodorowsky experienced an unhappy and alienated childhood, and so immersed himself in reading and writing poetry. Dropping out of college, he became involved in theater and in particular mime, working as a clown before founding his own theater troupe, the Teatro Mimico, in 1947. Moving to Paris in the early 1950s, Jodorowsky studied mime under Étienne Decroux before turning to cinema, directing the short film Les têtes interverties in 1957. From 1960 he divided his time between Paris and Mexico City, in the former becoming a founding member of the anarchistic avant-garde Panic Movement of performance artists. In 1966 he created his first comic strip, Anibal 5, while in 1967 he directed his first feature film, the surrealist Fando y Lis, which caused a huge scandal in Mexico, eventually being banned.
He immersed himself in reading, and also began writing poetry, having his first poem published when he was sixteen years old, alongside associating with such Chilean poets as Nicanor Parra, Stella Díaz Varín and Enrique Lihn. Becoming interested in the political ideology of anarchism, he began attending college, studying psychology and philosophy, but stayed for only two years. After dropping out, and having an interest in theatre and particularly mime, he took up employment as a clown in a circus and began a career as a theatre director. Meanwhile, in 1947 he founded his own theatrical troupe, the Teatro Mimico, which by 1952 had fifty members, and the following year he wrote his first play, El Minotaura (The Minotaur). Nonetheless, Jodorowsky felt that there was little for him left in Chile, and so that year he moved to Paris, France.