Born in Los Angeles, California, on July 10, 1969, she is the daughter of Bridget (Mori) and the actor David Hedison. Hedison is of Italian and Armenian heritage. She attended the State University of New York at Purchase and University of California, Los Angeles (UCLA).

Alexandra Hedison is a fine art photographer. Hedison first exhibited her series of abstract landscapes in 2002 at Rose Gallery in Bergamot Station, Los Angeles with Robert Polidori, Virginia Beahan and Laura McPhee, David Maisel, Alexandra Rowley and Joshua Bernstein.

As a photographer, in 2005, she exhibited the (Re)Building series, which addressed themes of loss, transition and recovery while using construction as a metaphor for memory in the architecture of the subconscious. Her series of large format photographs entitled Ithaka, which takes its title from the CP Cavafy poem of the same name, was shot in the temperate rain forest of North America. First exhibited in London, Ithaka was included in The New Yorker’s 2008 Passport to the Arts and Month of Photography Los Angeles the following year.

Hedison was selected by Barclays Capital for international sponsorship in 2008.

In 2009 Hedison published a series of books sponsored by the Center of Cultural Intelligence in Singapore.

In 2009, the Ithaka series was exhibited at Frank Pictures Gallery in Santa Monica, California. This exhibition was the Month of Photography Los Angeles (MOPLA) Official Opening Night Exhibition, in conjunction with Pro’jekt LA. In 2010, her solo show “In the Woods” was exhibited at Meredith Gunderson Projects in London, UK. The same year Hedison showed Ithaka in a solo exhibit at Mews 42 Gallery in London, UK.

In 2012, her work series Everybody Knows This Is Nowhere was exhibited in a solo show at Diane Rosenstein Gallery in Beverly Hills, California.

In 2013, Hedison was selected in the “My Aim Is True” exhibition at the Frostig Collection, Los Angeles with William Eggleston, Vivian Maier, Sebastião Salgado, Cindy Sherman, Taryn Simon, Cy Twombly, Diana Walker and Andy Warhol.

In 2013, Hedison was part of “First Anniversary- Exhibition of Paintings and Sculpture and Photographs” at Diane Rosenstein Fine Art, Los Angeles, CA in a group exhibition with John Adelman, Carmen Argote, Sarah Awad, Marco Breuer, Thomas Downing, Charles Fine, Eben Goff, Cleve Gray, Arnold Helbling, John M. Miller, Louise Nevelson, J. Alvaro Perdices, and John Sisley.

Hedison is openly lesbian, and was in a relationship with Ellen DeGeneres from 2000 to 2004. In April 2014, Hedison married Jodie Foster, after dating for a year.

In 2016 Hedison exhibited in “Both Sides of Sunset – Photographs of Los Angeles” at Kopeikin Gallery, Los Angeles, CA (with Bruce Davidson, Camilo Jose Vergara, David Drebin, David Maisel, Dennis Keeley, Ed Panar, Ed Ruscha, Florian Maier-Aichen, Gary Leonard, Graciela Iterbide, Grant Mudford, John Humble, Kevin Kooley, Lisa Kereszi, Lise Sarfati, Lynn Saville, Mark Ruwedel, Mark Swope, Matthew Porter, Mike Slack, Mitch Dobrowner, Robbert Flick, Sam Cormen, Tim Street-Porter, Todd Hido, Warren Neidich & Zoe Crosher)

In 2016 “Everybody Knows This Is Nowhere” opened at the Centro Cultural de Cascais, Cascais, Portugal, an exhibit that included photography and film installations. The show in Cascais, Portugal was named in Time Out Magazine as one of the top ten exhibitions in Lisbon during 2016.

In 2017 Alexandra Hedison and Jodie Foster co-chaired the 14th edition of the Hammer Museum’s annual Gala in the Garden with Robert Soros and Tomas Maier.