Such was the immense success of Cooper's solo project that he decided to continue as a solo artist, and the original band became officially defunct. Bruce, Dunaway, and Smith would go on to form the short-lived band Billion Dollar Babies, producing one album—Battle Axe—in 1977. While occasionally performing with one another and Glen Buxton, they would not reunite with Alice until October 23, 1999, at the second Glen Buxton Memorial Weekend for a show at CoopersTown in Phoenix. They reunited for another show, with Steve Hunter on guitar, on December 16, 2010, at the Dodge Theatre in Phoenix. This lineup would perform together again (televised) on March 14, 2011, at the induction of the original Alice Cooper group into the Rock and Roll Hall of Fame, as well as on May 11, 2011, at London's Battersea Power Station at the Jagermeister Ice Cold 4D event (webcast). Bruce, Dunaway, and Smith appeared on three tracks they co-wrote on Alice's 2011 album Welcome 2 My Nightmare. In 2017, they appeared on two tracks they co-wrote on Alice's album Paranormal, released in July, and in November they joined his current live band for five tour dates in the United Kingdom.
In January 2010, it was announced that Alice would be touring with Rob Zombie on the "Gruesome Twosome" tour. In May 2010, Cooper made an appearance during the beginning of the season finale of the reality-show American Idol, in which he sang "School's Out".
During 2010, Cooper began working on a new album, dubbed Welcome 2 My Nightmare, a sequel to the original Welcome to My Nightmare. In a Radio Metal interview, he said that "We'll put some of the original people on it and add some new people ... I'm very happy with working with Bob (Ezrin) again."
On December 15, 2010, it was announced Cooper and his former band would be inducted into the Rock and Roll Hall of Fame. The induction ceremony took place March 14, 2011, where Cooper was inducted by fellow horror-rocker Rob Zombie. Original members Bruce, Cooper, Dunaway, and Smith all made brief acceptance speeches and performed "I'm Eighteen" and "School's Out" live together, with Steve Hunter filling in for the late Glen Buxton. Alice showed up for the event wearing a (presumably fake) blood-splattered shirt and had a live albino Burmese python wrapped around his neck. Cooper told Rolling Stone Magazine that he was "elated" by the news and that the nomination had been made for the original band, as "We all did go to the same high school together, and we were all on the track team, and it was pretty cool that guys that knew each other before the band ended up going that far".
Throughout his career, Cooper's philosophy regarding politics is that politics should not be mixed with rock music. Cooper has usually kept his political views to himself, and in 2010 said, "I am extremely non-political. I go out of my way to be non-political. I'm probably the biggest moderate you know. When John Lennon and Harry Nilsson used to argue politics, I was sitting right in the middle of them, and I was the guy who was going 'I don't care.' When my parents would start talking politics, I would go in my room and put on the Rolling Stones or the Who as long as I could avoid politics. And I still feel that way."