Less than a week later on November 30, Iverson and his representatives met with a Philadelphia 76ers delegation about returning to his former team, and accepted a contract offer two days later. General manager Ed Stefanski declined to go into the terms of the agreement, but an unnamed source told the Associated Press that Iverson agreed to a one-year non-guaranteed contract at the league minimum salary. Iverson would receive a prorated portion of the $1.3 million minimum salary for players with at least 10 years of experience, and the contract would become guaranteed for the remainder of the 2009–10 season if he remained on the roster on January 8, 2010. Stefanski said the team made the decision to pursue Iverson after starting guard Lou Williams suffered a broken jaw and was expected to miss at least 30 games.
On January 3, 2010, he returned to Denver to face the Nuggets; Iverson scored 17 points and had seven assists in the 108-105 win. He was voted as a starter for the All-Star Game for the 11th straight season. He scored a season-high 23 points (on 56% shooting from the field) in a 99-91 loss to Kobe Bryant and the defending champion Lakers.
On February 22, 2010, Iverson left the 76ers indefinitely, citing the need to attend to his 4-year-old daughter Messiah's health issues, which he revealed years later as Kawasaki Disease. On March 2, Stefanski announced Iverson would not return to the 76ers for the rest of the season to deal with the personal matter. His final NBA game was a loss against Derrick Rose and the Chicago Bulls on February 20, 2010.
On October 26, 2010, Yahoo! Sports reported that Iverson agreed in principle to a two-year, $4 million net income contract with Beşiktaş, a Turkish Super League team competing in the second-tier level of pan-European professional basketball, the EuroCup (the competition below the EuroLeague level). The club announced the signing at a press conference in New York City, on October 29, 2010. Wearing jersey #4, Iverson made his debut for Beşiktaş on November 16, 2010, in a EuroCup 91-94 loss to Serbian side Hemofarm. Iverson scored 15 points in 23 minutes.
On March 2, 2010, Tawanna Iverson filed for divorce, seeking custody of their children, as well as child support and alimony payments. According to Iverson, the couple were back together less than a month after the divorce was finalized in 2013.