In 2014, Clayton was cast as one of leads alongside Edwina Findley, Heather Hemmens, Zulay Henao, and April Parker Jones in the Oprah Winfrey Network prime time soap opera If Loving You Is Wrong. The series ended in 2020 after five seasons. Later in 2014, she was cast opposite Miles Teller and Katey Sagal in the biographical drama film Bleed For This about boxer, Vinny Pazienza. In addition to Bleed For This, Clayton is the female lead in two additional feature-length films set for release in 2016, the comedy, The Bet and the drama, Bad Frank. In 2017, she played the leading role in the Lifetime Movie Cradle Swapping, and the following year in Mommy's Little Angel.