Her career and reputation as a ‘wild child’ made her a British tabloid figure and she became only more well known when she married Duran Duran bassist John Taylor in 1999 at age 19. They moved from the United Kingdom to Los Angeles the following year. Upon arrival in L.A., de Cadenet embarked upon a short film career, appearing in: Four Rooms (1995), a collaborative film by Allison Anders, Alexandre Rockwell, Robert Rodriguez, and Quentin Tarantino; Fall (1997); and Brokedown Palace (1999).

Her career then turned to fashion and portrait photography, working for magazines such as Spin, Jane and Harper’s Bazaar, among others. In 2005, she published a photo book entitled Rare Birds. Her other celebrity popular culture subjects have included Drew Barrymore, Sofia Coppola, Demi Moore, Olivia Wilde, Mary J. Blige, Keanu Reeves, Beck Hansen, and the members of The Strokes.

In 2006, she married guitarist Nick Valensi of American rock band The Strokes, after meeting at one of the band’s performances in 2002. Their twin children Ella and Silvan were born in 2007.

In the 2010s, she returned to television and worked on a series of eponymous interview projects. In 2011, it was announced that de Cadenet would be the host of a new television interview series called The Conversation with Amanda de Cadenet, airing on the Lifetime Channel, with Demi Moore as a co-executive producer. On the show, de Cadenet has interviewed female guests such as Hillary Clinton, Lady Gaga, Portia de Rossi, Rita Wilson, Gwyneth Paltrow, Zoe Saldana and Jane Fonda. During the production of The Conversation, she developed a second show with Lifetime, a weekly late-night television talk show featuring de Cadenet entitled, Undone with @AmandadeCadenet. The show ran for six episodes in 2014. In 2018, she worked with Showtime to develope a pilot for a half-hour weekly news-magazine show tentatively titled Now What With Amanda de Cadenet. The show did not air. In 2019, she developed a ten-episode spin-off podcast of The Conversation in partnership with Spotify.

In 2016, she founded Girlgaze, a global online platform which connects female-identifying creatives with different brands. Speaking on her role as CEO and past experience as a photographer, she said “I’m interested in the stories [women and nonbinary] people have to tell, because of my own experience of being shut out of so many creative opportunities because of my gender.” For this work, Fast Company named her one of 2020’s “Most Creative People in Business.”

In 2017, she released her second book and collection of photography, #girlgaze: How Girls See the World. This was followed in 2018 by a book of essays published by Harper Wave titled It’s Messy: On Boys, Boobs, and Badass Women.