Perez was discovered in Fort Wayne by a talent scout and signed to the independent record label Powerhowse/Silverstone Records in 2001. Her debut album Where U At? was released in 2002 and included the singles “Never” and “Angel”. “Never” peaked at No. 10 on the Billboard Hot 100 sales chart, but the album itself did not see much success until it was re-released by Virgin Records to a wider distribution area under the new title, “Angel”. Perez’s most popular single to date, “Angel”, peaked at No. 20 on the Hot 100 sales chart and No. 3 at Top 40 Radio.

Subsequently, she took time off to care for her mother who was diagnosed with cancer. In 2004 Quinn’s Silverstone/Powerhowse label partnered to released her second album, this time with Virgin Records, as a joint effort.

Perez notably charted at No. 7 on the popular MTV viewer request show Total Request Live. She has had moderate success since departing from the original producers in 2005.

In 2007 Upstairs Records released a special album dedicated to Perez’s mother’s death. The lone single from that album, “Candy Kisses,” did not break any records, but it had success on the Top 40/Rhythmic Chart, peaking at No. 17.

In 2013, Perez and A-Hype Records released the single “Freak For The Weekend”, the first single from the album Unexpected.

On October 21, 2016, Perez announced that she was working on her sixth studio album in an interview with Power 98.3 & 101.9. She intended for a December 2016 release but the album process has continued into 2020. She continues to post many clips of material she is working on via her official Facebook, Twitter, and Instagram pages.

In February 2017 Perez announced that she will release a limited edition Greatest Hits album entitled 15 Years of Greatest Hits that will only be available for purchase at her live shows.

October 2, 2019, Amanda Perez announced that she and her wife Ana Laura Perez, had their son Sebastian King Perez.