Blaire studied acting at age fifteen when she first started classes at The Sanford Meisner Center for the Arts in Los Angeles, California. After a summer studying Shakespeare with the British American Drama Academy in London, she began working with Oscar-nominated actress Lindsay Crouse, who directed her towards the Atlantic Theater Company's two year conservatory program in New York City. After graduating, she completed Atlantic's LA Program of master classes with David Mamet, Felicity Huffman, Clark Gregg and others. On August 23, 2013, it was announced that she had been promoted to a series regular on the HBO television series, True Blood.