In 2012, Ortiz was cast as a lead character on the ABC comedy-drama pilot Devious Maids. While ABC chose not to pick it up to series, Lifetime picked up the pilot with a thirteen-episode order. The series premiered June 23, 2013, on Lifetime with positive reviews from critics. In the show, she plays the lead role of Marisol Duarte (the alias of Professor Marisol Suarez). Also in 2013, Ortiz was special guest star in the ABC primetime soap opera, Revenge, as Bizzy Preston. In 2014, Ortiz guest-starred in episodes of two ABC shows: How to Get Away with Murder and Black-ish.