Lewis appeared with Diahann Carroll in the biopic The Natalie Cole Story. She also acted with Naomi Judd in A Holiday Romance, which was a television Christmas special. In 1998, she played Cassandra in the critically acclaimed feature, Down in the Delta.

In 2001, she played Brigette in an episode of Soul Food: The Series on Showtime, returning in 2003 for one episode, playing Dana. She also began her role as Hazel Aden in Degrassi: The Next Generation.

In 2002, she played Hilary Duff’s best friend Carla Hall in the made-for-television movie Cadet Kelly.

In 2003 and again in 2006, she was nominated in the category of Best Young Ensemble Performance in a TV Series (Comedy or Drama) for her role in Degrassi: The Next Generation at the Young Artist Awards.

On September 20, 2005, her first album, Float Away, was released in Canada only. On October 10, 2010, Lewis released a second album, 5-4-3-2-1, free via her website.

In 2006, after five series, her character graduated and Lewis left Degrassi to “do something new”.

In 2009, she appeared in the Nickelodeon’s musical film Spectacular!. She played Robin, a member in a high school choir, Spectacular, broadcast on February 16, 2009.

In 2011, she played a minor role in the musical Hairspray which travelled around Canada.

In 2013, she created and starred in her own web series called Black Actress, which can be seen on Issa Rae’s YouTube channel.