Marcovicci was born in Manhattan, to Helen Stuart, a singer, and Eugen Marcovicci, a physician and internist of Romanian descent. Her father was 63 when she was born and died when she was 20. In her teens she decided that she wanted to be a singer, but instead majored in drama. In a 1972 interview, she looked back at this period without enthusiasm:

Marcovicci left school and started making her way into show business as a singer, appearing on The Mike Douglas Show and The Merv Griffin Show. As an actress, she debuted in commercials and soon became better known as Dr. Betsy Chernak Taylor on the television soap opera Love is a Many Splendored Thing from 1970–1973. She appeared in the second pilot film for the television series Harry O, titled Smile Jenny, You’re Dead. She was nominated for a Golden Globe award for the New Star of the Year in 1977 for the film, The Front (1976).

She married actor Daniel Reichert in 1993. The couple separated in 2004, and are now divorced. They have a daughter, Alice Wolfe Reichert.

She is the recipient of several awards and honors including the Mabel Mercer Foundation’s 2007 Mabel Award and three Lifetime Achievement Awards—honored by the Manhattan Association of Cabarets and Clubs, the Licia Albanese-Puccini Foundation, and by a Bob Harrington Backstage Bistro Award. In recognition of her accomplishments in the arts, Andrea has received honorary degrees from Trinity College in Hartford, CT and the Memphis College of Art. In addition, “The Andrea Marcovicci Suite” at the Algonquin Hotel, dedicated in 2006 on her twentieth anniversary at the Oak Room, contains memorabilia of her work in theatre, film, television, and on the concert stage.

In 2008 Marcovicci celebrated her 22nd season at the legendary Oak Room of the Algonquin Hotel with Marcovicci Sings Movies II. A very special 60th Birthday concert followed in May 2009 at Town Hall in NYC, celebrating Andrea’s contribution to the American Songbook. To commemorate this event her personal record label, Andreasong Recordings, Inc., released a compilation CD titled As Time Goes By: The Best of Andrea Marcovicci, her 17th album and/or CD.