Codrescu published his first poems in Romanian under the pen name Andrei Steiu. In 1965 he and his mother, a photographer and printer, were able to leave Romania after Israel paid US$2,000 (or US$10,000, according to other sources) to the Romanian communist regime for each of them. After some time in Italy, they moved to the United States in 1966, and settled in Detroit, where he became a regular at John Sinclair’s Artists and Writers’ Workshop. A year later, he moved to New York, where he became part of the literary scene on the Lower East Side. There he met Allen Ginsberg, Ted Berrigan, and Anne Waldman, and published his first poems in English.

In 1970, his poetry book, License to Carry a Gun, won the “Big Table Poetry Award”. He moved to San Francisco in 1970, and lived on the West Coast for seven years, four of those in Monte Rio, a Sonoma County town on the Russian River. He also lived in Baltimore (where he taught at Johns Hopkins University), New Orleans and Baton Rouge, publishing a book every year. During this time he wrote poetry, stories, essays and reviews for many publications, including The New York Times, the Chicago Tribune, the Los Angeles Times, Harper’s, and the Paris Review. He had regular columns in The Baltimore Sun, the City Paper, Architecture, Funny Times, Gambit Weekly, and Neon.

In 1981, Codrescu became a naturalized citizen of the United States. He is the editor and founder of the online journal Exquisite Corpse, a journal of “books and ideas”. He reigned as King of the Krewe du Vieux for the 2002 New Orleans Mardi Gras season. He has two children, Lucian and Tristan, from his marriage to Alice Henderson. He is currently married to Laura Cole Rosenthal.

In 1989, Codrescu covered the Romanian Revolution of 1989 for National Public Radio and ABC News’s Nightline. His renewed interest in the Romanian language and literature led to new work written in Romanian, including Miracle and Catastrophe, a book-length interview conducted by the theologian Robert Lazu, and The Forgiven Submarine, an epic poem written in collaboration with poet Ruxandra Cesereanu, which won the 2008 Radio România Cultural award. His books have been translated into Romanian by Ioana Avadani, Ioana Ieronim, Carmen Firan, Rodica Grigore, and Lacrimioara Stoie. In 2002 Codrescu returned to Romania with a PBS Frontline World video crew to “take the temperature” of his homeland and produced the story, “My Old Haunts”. In 2005 he was awarded the prestigious international Ovidius Prize (also known as the Ovid Prize), previous winners of which include Mario Vargas Llosa, Amos Oz, and Orhan Pamuk.