Andreja Pejic

Following the 1999 NATO bombing of Yugoslavia, Pejić's mother felt unsafe and decided to initiate the process of emigration to Australia. In 2000, the family moved to Melbourne, Victoria, Australia, as political refugees when Pejić was eight years old.

Pejić was initially notable for modelling both masculine and feminine clothing. In the Paris fashion shows of January 2011, Pejić walked both the men's and women's shows for Jean-Paul Gaultier and the men's shows for Marc Jacobs. In May 2011, her magazine cover for the New York-based magazine Dossier Journal—in which Pejić, with long blond locks in curlers, is pictured taking off a white shirt —was ruled too risqué by US bookstores Barnes & Noble and Borders, which covered the image with an opaque sleeve. Concerns were expressed that customers would read Pejić, who at the time was presenting as gender fluid, as a topless woman.

At the Stylenite in July 2011, Pejić appeared on the catwalk both in masculine and feminine clothes from Michalsky. The following year, she modeled bridal creations by Spanish designer Rosa Clara at Barcelona's Bridal Week 2013.

Pejić ranked number 18 on Models.com's Top 50 Models list in 2011, was named one of Out's Most Compelling People, and was ranked number 98 in FHM magazine's 100 Sexiest Women in the World 2011, an award that was criticised for its hostile tone to transgender individuals, especially transgender women; the magazine referred to Pejić as a "thing", commenting, "Pass the sick bucket." FHM subsequently removed the copy accompanying Pejić's entry and posted an apology.

On 6 August 2012, Pejić appeared as a guest judge on Britain & Ireland's Next Top Model. The following year, Pejić appeared alongside Iselin Steiro, Saskia de Brauw, Tilda Swinton and David Bowie in the video for Bowie's 2013 single "The Stars (Are Out Tonight)". In late 2013, she made her acting debut playing Radu the Beautiful in the short-lived Turkish television series Fatih, which is based on the life of Mehmed the Conqueror.

In late 2013, Pejić underwent sex reassignment surgery. In September 2014, Pejić announced plans on the Kickstarter crowdfunding platform to create a film about her reassignment surgery and life as a woman. Pejić started off with a projected goal of $40,000, ultimately exceeding the target funding goal. Pejić had previously dated Are You the One? cast member Remy Duran.

Pejić became the first openly transgender model profiled by Vogue, in its May 2015 issue, and also became the first-ever trans woman to sign a cosmetics contract. In 2016, Pejić was awarded "Best International Female Model" by GQ Portugal and the following year she made history by becoming the first transgender woman to appear on the cover of GQ. Pejić made her major film debut in the 2018 crime thriller film The Girl in the Spider's Web.