In 2007, Hussie launched the website MS Paint Adventures to host comics he had created as forum games. The most popular of Hussie's works is the webcomic Homestuck, which ran from 2009 to 2016. It tells the story of a group of four kids who play a computer game called Sburb and inadvertently cause the end of the world. A sequel, Homestuck^2: Beyond Canon, was released in late 2019.
