In May 2019, Neil interviewed Ben Shapiro, an American conservative commentator, on Politics Live on BBC Two. Shapiro was promoting his new book, The Right Side of History, which discusses Judeo-Christian values and asserts their decline in the United States. Several combative instances during the interview gained viral attention, including Shapiro walking out. Shapiro later apologised for the incident.
During the 2019 Conservative Party leadership election, Neil interviewed candidates Jeremy Hunt and Boris Johnson, in The Andrew Neil Interviews. Director of BBC News Fran Unsworth hailed it as "a masterclass of political interviewing".
In August 2019, the BBC announced that Neil would host a prime-time political programme that would run through autumn 2019 on BBC Two, called The Andrew Neil Show. The show included "in-depth analysis and forensic questioning of key political players". It was suspended due to the COVID-19 pandemic in March 2020 and then cancelled as the BBC went through with budget cuts.
On 24 September 2019, Neil presented a live programme on BBC One entitled BBC News Special: Politics in Crisis, addressing the Supreme Court judgement which deemed Boris Johnson's prorogation of parliament unlawful. In the run-up to the 2019 general election, Neil interviewed all the leaders of the main political parties, excluding Johnson, having delivered a monologue in The Andrew Neil Interviews issuing him a challenge to participate.