In the lead-up to the French Open, Murray beat No. 9, Nikolay Davydenko at the Monte Carlo Masters, the first time he had beaten a top ten player on clay, though he lost to Nadal in the semi-finals. Murray was upset in round two of the Rome Masters by qualifier Juan Mónaco, and he reached the quarter-finals of the Madrid Masters, losing to Juan Martín del Potro. During this time Murray achieved the highest ever ranking of a British male in the Open Era when he reached the No. 3 ranking on 11 May 2009. Murray reached the quarter-finals of the French Open, but was defeated by Fernando González in four sets.
In March, Murray split with coach Ivan Lendl, who had been widely praised for helping Murray achieve his goal of winning Grand Slam titles. At the 2014 Miami Masters, Murray defeated Matthew Ebden, Feliciano López and Jo Wilfried Tsonga but lost to Djokovic in the quarter-finals. In the Davis Cup quarter-finals against Italy, he beat Andreas Seppi in his first rubber, then teamed up with Colin Fleming to win the doubles rubber. Murray had only beaten one top ten player on clay, Nikolay Davydenko, back in 2009, and so in his final singles match, was stunned by Fabio Fognini in straight sets, which took Great Britain to the deciding final rubber. However, in this match his compatriot, James Ward was defeated by Andreas Seppi, also in straight sets, knocking Murray and Great Britain out of the Davis Cup.
Murray has played against Rafael Nadal on 24 occasions since 2007, with Nadal leading 17–7. Nadal leads 7–2 on clay, 3–0 on grass and 7–5 on hard courts. The pair regularly meet at Grand Slam level, with nine out of their twenty-four meetings coming in slams, with Nadal leading 7–2 (3–0 at Wimbledon, 2–0 at the French Open, 1–1 at the Australian Open and 1–1 at the US Open). Eight of these nine appearances have been at quarter-final and semi-final level. They have never met in a slam final, however, Murray leads 3–1 in ATP finals, with Nadal winning at Indian Wells in 2009 and Murray winning in Rotterdam the same year, Tokyo in 2011, and at Madrid in 2015.
Murray and Stan Wawrinka have played 21 times with Murray leading 12–9. Murray leads 8–4 on hard courts and 3–0 on grass courts while Wawrinka leads 5–1 on clay courts. They have also met seven times in Grand Slam tournaments with Wawrinka holding a slight 4-3 edge. They have contested some close matches and one of their most notable meetings was in the 2009 Wimbledon fourth round, which Murray won in five sets; this was the first men's match to be played under the Wimbledon roof, having the latest finish for a Wimbledon match at the time. Wawrinka also ended Murray's title defence at the 2013 US Open quarter-finals with a comfortable straight sets victory. Other close matches between the two include three-set wins for Murray at the 2008 Canada Open and 2011 Shanghai Masters, and the 2010 US Open which Wawrinka won in four sets.
Murray plays an all-court game with an emphasis on defensive baseline play, and in 2009 professional tennis coach Paul Annacone stated that Murray "may be the best counterpuncher on tour today." His strengths include groundstrokes with low error rate, the ability to anticipate and react, and his transition from defence to offence with speed, which enables him to hit winners from defensive positions. His playing style has been likened to that of Miloslav Mečíř. Murray also has one of the best two-handed backhands on the tour, with dynamic stroke execution while he primarily uses his forehand, which is more passive, and a sliced backhand to let opponents play into his defensive game before playing more offensively. Tim Henman stated in 2013 that Murray may have the best lob in the game, succeeding Lleyton Hewitt. Murray's tactics often involve passive exchanges from the baseline. He is capable of injecting sudden pace into his groundstrokes to surprise his opponents who are used to the slow rally. Murray is also one of the top returners in the game, often able to block back fast serves with his excellent reach and ability to anticipate. For this reason, Murray is rarely aced.
In 2009, German manufacturer Adidas and Murray signed a five-year-deal worth £30 million. This included wearing their range of tennis shoes. The contract with Adidas allowed Murray to keep his shirt sleeve sponsors Shiatzy Chen, Royal Bank of Scotland and Highland Spring. Before he was signed by Adidas in late 2009, he wore Fred Perry apparel. At the end of their contract together Adidas decided not to re-sign with Murray, and he began a 4-year partnership with athletic apparel company Under Armour in December 2014, reportedly worth $25 million. Murray signed with Castore for the 2019 season which Murray called his last deal before announcing his retirement.
Murray is a founding member of the Malaria No More UK Leadership Council and helped launch the charity in 2009 with David Beckham. Footage from the launch at Wembley Stadium can be seen on YouTube and the charity's website. Murray also made 'Nets Needed', a short public service announcement, for the charity to help raise awareness and funds to help in the fight against malaria. Murray has also taken part in several charity tennis events, including the Rally for Relief events that took place prior to the start of the 2011 Australian Open.