By 2004, the Body Shop had 1980 stores, serving more than 77 million customers throughout the world. It was voted the second most-trusted brand in the United Kingdom, and 28th top brand in the world.
In 2004, Roddick was diagnosed with liver cirrhosis due to long-standing hepatitis C. She did not reveal her illness until 14 February 2007. Roddick said, "I have hepatitis C. It's a bit of a bummer, but you groan and move on". She subsequently promoted the work of The Hepatitis C Trust, and campaigned to increase awareness of the disease. On 30 August 2007, less than two weeks before her death, Roddick was a special guest in an episode of the live television programme Doctor, Doctor broadcast on Channel 5 in the UK. She discussed hepatitis C with the presenter and general practitioner, Mark Porter.
Roddick explained that her hepatitis C was unexpectedly diagnosed in 2004, following a blood test that was part of a medical examination needed for a life insurance policy. The blood test indicated abnormal liver function and subsequent blood tests diagnosed hepatitis C. Roddick explained that she had a large blood transfusion in 1971, after the birth of her younger daughter, and that she was convinced that the transfusion had infected her with hepatitis C. This was about twenty years before blood donors in the United Kingdom were screened for hepatitis C.