Li was a Teenternational Housemates of a Pinoy reality show in ABS-CBN Pinoy Big Brother: Teen Clash 2010 as the Diligent Daughter of Taiwan. She entered the Pinoy Big Brother house on Day 22 as one of the “Teenternational” housemates. After the first set of housemates was merged into one group in one half of the house, Big Brother picked another set of teenagers to live in the other half. Li was part of that set, composed of teenagers who weren’t pure Filipinos. Li was evicted from the Pinoy Big Brother house on Day 75, being the LAST housemate to get evicted on the show. One of the things that caught viewers’ attention during Li’s run on the show was her friendship with James Reid. She and Reid have a very devoted fanbase called the JamLi Poppers, who would throw lavish parties in their idols’ honor. In 2010, James Reid’s first interview on The Buzz, he was asked by Boy Abunda, Kris Aquino and KC Conception who he wanted to be paired with for his future projects. He answered “Honestly, Ann” which became a popular phrase among the Jamli Poppers. A few fan books inspired by the pair were released, including the Fan Fiction “Honestly, Ann”. The most famous one called “To the Beach” by Anna Ida.

Li set up a Facebook page in 2010 and made an online auction of her famous ‘yellow bunny hoodie’. The money out of these will be given to Lola Vita and Lola Lourdes, the two elderly people from Hospicio de San Jose who visited the Pinoy Big Brother house. In January 2011, Li visited Lola Vita and Lola Lourdes at the Hospicio de San Jose and celebrated a pre 16th birthday party with her fans. Li’s clothing brand (DNA) then sponsored a charity foundation (Future Faces Manila) during their runway event where she styled the models wearing her clothing brand and walked on the runway herself.

She had a special participation role on GoodVibes series in 2011. Playing the role of Lucy Ledesma, the famous celebrity who was linked to Spender Ziff.

On July 24, 2011, Li together with Fretzie Bercede were featured in James Reid and Bret Jackson’s original song “Can’t Dance” released under Star Records. They launched their first digital album entitled We Are Whatever on ASAP Rocks.

In 2011, she worked as a fashion intern for Bang Pineda while taking a short course in fashion design at a local fashion institute. During Li’s weekends, she helped the crew style the celebrity guests for the variety show ASAP. At times when she is invited as a guest herself, she would be working as a stylist and as a performer for the show. During her internship she also went to New York City and Seattle with the crew for International Fashion Tour. She was also a finalist for TeenVogue’s Rouge Coco Shine Hydrating Sheer Lipshine video competition for Chanel.

On October 1, 2011 Li won the title “Ultimate Female Teen Fashionista” in a poll site “Piece of Speaks” a blog confirms a straight to the point topics about Philippines favorite actors and actresses which Li earn 2,548 votes. Li beats 5 contenders for the Ultimate Teen Fashionista. It is quoted on the blog that Li won because she has her own style with an aura of a princess and most of her outfits and dresses are unique in her own ways.

After winning as Piece of Speak’s Ultimate Female Teen Fashionista. On October 4, 2011, Li also won the title “Most Popular Teen Star of 2011” with 181,325 total points out from poll votes, Facebook likes and comment posting by “EnteRvrexWorld”, an Ultimate Philippines entertainment poll site.

In 2012, she finally began her blog to document her fashion endeavors.

In 2013, Li was chosen and photographed by Leslie Kee for his 15th Anniversary photo book called “Super Love” as one of the 500 well-known artists, dancers, creators, actors, models and other personalities dressed in a single scarf, drawn from the exclusive “Comme des Carrés” collaborative collection jointly produced by Hermès and Comme des Garçons’ Rei Kawakubo. She also worked for Roberto Cavalli, Imane Ayisi and Emanual Ungaro as an intern during Paris Fashion Week while on other days she’d be seen on front rows at shows like Elie Saab, Ralph and Russo, and Issey Miyake. Since then she has done editorial shoots and collaborated with brands such as Calvin Klein, Marimekko, and Kenzo.

The Shorty Awards, hailed as the Oscars of Twitter by The New York Times, announced the winners in 36 categories last March 28, 2011 in New York City. Li took home the award for fashion, presented by Aasif Mandvi, emerging as the winner with the most votes out of 1,861 nominees, which include One Direction member, Harry Styles, Demi Lovato, Selena Gomez, Taylor Swift and other Hollywood celebrities. Other winners were the Jonas Brothers for Music and How I Met Your Mother’s Neil Patrick Harris for Actor. To view the complete list of winners, go to The Shorty Awards website. Li was nominated again for the same category ‘Fashion’ on the 4th annual Shorty Awards in 2013.

In 2015, the Grand Hyatt, Singapore, invited Li to show her perspective of ‘Living Grand’, where she attended the Chinese New Year event wearing a modern QiPao look that she deconstructed.

L’Officiel Manila included her in the list of ‘From East to West: 9 Filipinas Taking The Fashion World By Storm’ and wrote ‘we dare to ask: what else is this 21-year old capable of?’ because of her achievements in the Fashion Industry. She relaunched her website as a webzine on June 19, 2016.

In 2017, Forbes magazine listed Li on their “30 Under 30” Asia List under “The Arts” and is the youngest on the list at 22. She is also amongst the youngest in the category “Celebrities” alongside Lorde, Margot Robbie, Kris Wu, etc. On July 17, 2017 it was announced by Forbes on and share by Li that she would be attending the Summit in Manila, Philippines. She was invited by Forbes as a notable participant and panelist during the Under 30 Summit where she spoke about ‘Art as a Medium for Change’. She was appointed as a judge for Miss World Philippines 2017 which aired on GMA Network on September 3, 2017. She also presented the award for Multimedia where she awarded Laura Lehmann who won the title and proceeded to be crowned Miss World Philippines 2017.