Throughout the 1970s, Girardot came back and forth between drama and comedy, proving herself an adept comedian in such successful comedies as Claude Zidi's La Zizanie, Michel Audiard's She Does Not Drink, Smoke or Flirt But... She Talks or Philippe de Broca's Dear Detective. In 1974, she starred in the hit teen movie, La Gifle, as Isabelle Adjani's mother. In 1972, she said in an interview to The New York Times, citing as Exhibit A her role as a sideshow freak in The Ape Woman, “I think I’ve proven that I’m opposed to typecasting. I believe that the acting of any role — from duchess to kitchen slavey — must be a form of transformation". In 1977, she won her first César Award for Best Actress portraying the title character in the drama Docteur Françoise Gailland. Throughout the 1970s, she was the highest-paid actress in France, and was nicknamed "La Girardot" by the press due to the fact that her name alone was enough to guarantee the success of a film. Indeed, between the release of Live for Life in 1967 and Jupiter's Thigh in 1980, 24 of her films have attracted more than one million admissions in France.
On stage she had a triumph in 1974 with Madame Marguerite, which became her signature role that she reprised on numerous occasions until 2002. That year she was awarded the Molière Award for this role, along with a Honorary Molière Award for her entire stage career.