In 2006, she had four releases, the first being S. S. Rajamouli’s Vikramarkudu, where she was paired with Ravi Teja. The film went on to become very successful and got her much recognition, making her very popular in Telangana and Andhra Pradesh. Kishore of Nowrunning.com said “The high points of the movie are the flawless acting of Raviteja and the lusciousness of Anushka. Raviteja has got all the ingredients that an actor should have and Anushka has all the assets to that a woman ought to have.” and Sify said that Anushka “is definitely a highlight.”

Her first release in 2007 was Lakshyam which was a success in box office, after which she starred in Raghava Lawrence’s Don opposite Nagarjuna again. The former, in particular, succeeded at the box office. In 2008 she had appeared in six films. Okka Magaadu was the first release, in which she played one of three female leads. Nandamuri Balakrishna was the actor opposite her in Okka Magaadu. Her next releases Swagatam alongside Jagapati Babu and Bhumika Chawla and Baladur opposite Ravi Teja garnered poor reviews and box office returns. She next appeared in the film Souryam with Gopichand which became a box office hit.

In 2009, Anushka first starred in the blockbuster hit, the fantasy film Arundhati. In this heroine-centric film, she essayed two roles for the first time. It was a critical as well as commercial success. Critics heaped praise on Anushka for her performance. Idlebrain’s Jeevi wrote that she was “simply amazing in two roles” and that she did “exceptionally well with subtle yet impact creating performance”, while Rediff claimed that she was “brilliant and breathtaking in parts”, labelling Arundhati as “totally Anushka’s film”. Sify noted that she was “at her best with great performance”. She went on to win the Nandi Special Jury Award and the Filmfare Best Actress Award. Her next film was Billa, a remake of the 2007 Tamil film of the same name. The film received mixed reviews, with Rediff stating “Anushka has a super-toned body and indulges in quite a bit of skin show” but had “nothing much to do”, while Sify stated “Anushka was there to show her oomph and glamour which she has done full justice”. Her final release in 2009 was her second Tamil feature film, the action masala film Vettaikkaran with actor Vijay and it received generally unfavourable reviews. Rediff said, “Anushka, fresh from her success with Arundhathi, has been relegated to pretty bimbette again and appears conveniently during the romantic numbers of which Oru Chinna Thamarai takes the cake.” and Sify said, “Anushka has nothing much to do and hence goes unnoticed.”

She had a string of releases in 2010. She portrayed a prostitute in Krish’s anthology film Vedam which stars Allu Arjun. For her performance, she won the Filmfare Award for Best Actress, her second consecutive Filmfare Award. Her next Telugu film, Panchakshari, was another heroine-centric film where she again performed double roles. This was followed by the action comedy Khaleja, where she starred opposite Mahesh Babu for the first time in her career, Nagavalli, the Telugu remake of the Kannada film Aptharakshaka in which she portrayed the famous role of Chandramukhi and Ragada. She also made special appearances in the movies Kedi and Thakita Thakita. However all these 2010 releases failed to make an impact at the box office. Her sole Tamil release of 2010, the police story Singam co-starring Suriya was a high commercial success. Sify claimed, “Anushka is there only for glamour and songs, but does a decent job”. while Pavithra Srinivasan of Rediff stated, “Anushka, thankfully, has more to do than just prance around in skimpy clothes (which she does very well). She romances dutifully, but her part picks up when both she and Suriya are in Chennai, tangling with villains.”

In 2012, Anushka recollabored with in A. L. Vijay and Vikram in the action drama Thaandavam. Malathi Rangarajan stated that “the romance between Vikram and Anushka is a beautiful feature of Thaandavam.” She later appeared alongside Akkineni Nagarjuna in the fantasy film Dhamarukam, which was her first Telugu release after two years. Karthik Pasupulate from The Times of India said that Anushka “has little to do as far as performance goes and does a good job of upping the glam quotient”. Radhika Rajamani of Rediff claimed, “Anushka looks sweet. Nag and Anushka have good onscreen chemistry”. Oneindia claimed, “Anushka Shetty has less scope for acting, but she impresses you in song sequences.

Her first release in 2013 was Alex Pandian, an action-masala film, directed by Suraj, co-starring Karthi. The film was a critical and commercial failure. Her second release was Koratala Siva’s Mirchi opposite Prabhas. Idlebrain claimed, “Anushka is adorable in a naughty village belle, the dubbing also seems great and the character Vennela is the best role among her recent role in movies”. Rediff wrote, “Anushka is bubbly and peps up the film considerably”. Sify wrote, “Anushka looks beautiful and livens up the moments and praised her chemistry with Prabhas”. She was next seen in Singam II, the sequel to Singam (2010), reprising her role from the first part. Sify said, “Anushka looks jaded, has nothing to do but sizzle with Suriya in two songs” while The Times of India stated, “Anushka is forced to take a back seat even as she reprises her role of Kavya.”

Anushka next release was Selvaraghavan’s fantasy adventure film Irandam Ulagam opposite Arya, that saw her playing a dual role again, the third time in her career. Anushka played Ramya, a doctor and Varna, a high spirited, warrior-like character, in a parallel world. Rediff wrote, “Anushka not only shares equal screen space with Arya, but also plays quite a significant role. In fact, the story revolves around her and she has performed admirably”. Behindwoods wrote, “As the shy doctor Ramya and as the fierce warrior Varna, Anushka is simply at her best showcasing a wide range of emotions and stunts. It is her performance that stands as a pivot for the rest of the story to take shape”. Her latest release is the Tamil film Lingaa opposite Rajinikanth, released in December 2014. She starred opposite Rajnikanth in Lingaa which opened to mixed reviews.

In 2015, she starred opposite Ajith Kumar in Yennai Arindhaal which opened to positive reviews. Her second release in 2015, is the first part of Baahubali directed by S. S. Rajamouli which became one of the top-grossing films in the Indian film industry.Anushka Shetty was referred to in the media as the “Lady Superstar”.The Hindu noted that, Anushka Shetty is gutsy to take on such a role and emotes through her powerful eyes. Her third release in 2015 was Gunashekar’s bilingual Rudhramadevi in which she portrays the title role of the queen of Kakatiya dynasty, Rudrama Devi opposite Allu Arjun and Rana Daggubati. AP Herald wrote, “Anushka Shetty was very believable and appreciable as a royal torrid and an honorable woman. Hers is a dual character, that of next to kin ‘Rudhradeva’ and of powerful ‘Rudhramadevi’ are superb. She plays her dual role in her characters in style and lends credibility to both the characters.” Her final release in 2015 was Size Zero where she played a plus-sized women.She got 2 movie in 2016 release as cameo appearance in Soggade Chinni Nayana and Oopiri

Her first film release in 2017 was Si3, in which she was paired with Surya for the third time in her career. In Om Namo Venkatesaya Shetty portrayed Krishnamma, a Goda Devi or Andal-inspired character. Her next release was Baahubali 2: The Conclusion. Shetty received a positive response for her portrayal of Yuvarani Devasena. The character of Devasena was highly praised by critics and Shetty’s portrayal was equally lauded. A Firstpost article noted that the female characters in the second part were the actual heroes of the saga.Comparing Devasena to Arjuna, the article described her as “a competitive warrior who can wield the bow and arrow with finesse”.It further noted how her character emphasized the need of freedom of choice writing that “in Devasena’s case by taking archery lessons, choosing her life partner and being given the right to reject a matrimonial alliance, she can be her own person and develop into a strong personality, who doesn’t break down even when chained for 25 years in the palace courtyard.”