Nayyar first met Asha in 1952, at the music recording of Chham Chhama Chham. He first called her for a film called Mangu (1954), and gave her a big break in C.I.D. (1956). However, it was the success of Naya Daur (1957) that made the duo very popular. After 1959, she was emotionally and professionally involved with Nayyar.

Asha Bhosle sang her first Bengali song in 1958 under the banner of HMV. The songs were duets with Binod Chattopadhyay and composed by Manna Dey. The following year, she recorded her very first “Pooja Songs” from HMV with music arranged by Dey again. She sang many pooja songs in Bengali. Rahul converted some Hindi tracks to Bengali such as “Gunjone Dole Je Bhramar” (made from Gunguna Rahe Hain Bawre in Aradhana), “Chokhe Name Bristi” (from Jane Kya Baat Hai), “Gungun Gunje” (from Pyaar Deewana Hota Hain). In the mid 1970s, she would frequently sing for Bengali songs tuned by Sudhin Dasgupta, Nachiketa Ghosh rtc. In 1975, she sang the duet “Sara Pyaar Tumhara” with Kishore Kumar in Anand Ashram and “Amar Swapno Tumi” in its Bengali version with the same title. In the 1970s, she sang a lot of songs in films such as Chhadmabeshi, Bandi, Mouchak, Anand Ashram etc. In 1980, she sang the Bhajan “Kunjo Bihari He Giridhari” in Mayer Ashirbad. In 1981, she sang the duet “Adho Alo Chhayate” with Kishore in Kalankini Kankanati. In 1982, she sang a Bengali Adhunik song “Kotha Hoyechilo” in Troyee for Debasri Roy. In 1986, the duet with Kishore Kumar “Chiridini Tumi Je Amar” composed by Bappi Lahiri. In 2014, she has created the album “Pancham Tumi Kothay” in honor of her husband Rahul Dev Burman’s 75th birth anniversary. In this album she has sung 8 songs previously composed by Burman. She has also sung in a 2014 film Parapar at the age of 81.

Asha’s house is situated in Prabhukunj Apt on the Peddar Road area of South Mumbai. Asha, at the age of 16, had eloped with 31-year-old Ganpatrao Bhosle. They separated in 1960. They have three children and five grandchildren. The eldest of her three children, Hemant Bhosle (named after Hemant Kumar), spent most of his early years as a pilot and quit to have a brief career as a music director. Bhosle’s daughter Varsha committed suicide on 8 October 2012; she was 56 years old and worked as a columnist for The Sunday Observer and Rediff.

Asha’s first husband Ganpatrao was her personal secretary. Their marriage failed miserably in 1960. Her husband and in-laws mistreated her. After a few years of marriage, Asha was turned out by a suspicious Ganpatrao and she went to her maternal home with two children while pregnant with her third child. She continued to sing in films to earn money. Asha married Rahul Dev Burman in 1980. This was the second marriage for both Rahul and Asha. Rahul, 6 years younger than her, earlier got divorced from Rita Patel in 1971.

Asha started her playback singing in Marathi with the mythological film Gokulcha raja. Since then Asha Bhosle has sung thousands of Marathi film songs, Bhavgeet (non-film songs). Natya sangeet from Master Deenanath Mangeshkar’s Marathi Sangeet natak has also been recorded in Asha Bhosle’s voice. During the 1950s and 60s, Asha and her sister Lata were the main playback singers for Marathi films. She won the 1962 Maharashtra government best singer award for the Marathi film Manini. In 1963 music director Vasant Desai used her voice with Talat Mehmood in the film, Molkarin.

In 1966, Bhosle’s performances in the duets from one of music director R.D. Burman’s first soundtracks, for the movie Teesri Manzil, won popular acclaim. Reportedly, when she first heard the dance number “Aaja Aaja”, she felt she would not be able to sing this westernised tune. While Burman offered to change the music, she refused, taking it as a challenge. She completed the song after ten days of rehearsals, and “Aaja Aaja”, along with such other songs as “O Haseena Zulfonwali” and “O Mere Sona Re” (all three duets with Rafi), became successful. Shammi Kapoor, the film’s leading actor, was once quoted as saying– “If I did not have Mohammad Rafi to sing for me, I would have got Asha Bhosle to do the job”. Bhosle’s collaboration with Burman resulted in numerous hits and a marriage. During the 1960-70s, she was the voice of Bollywood’s actress and dancer, Helen, on whom “O Haseena Zulfon Wali” was picturised. It is said that Helen would attend her recording sessions so that she could understand the song better and plan dance steps accordingly. Some of their other popular numbers include “Piya Tu Ab To Aaja” (Caravan) and “Yeh Mera Dil” (Don), among others.

Asha Bhosle has won seven Filmfare Best Female Playback Awards of 18 nominations. She won her first two awards in 1967 and 1968. (Mangeshkar asked not to be considered for the award nominations after 1969 to promote new talent). After receiving the award in 1979, Bhosle emulated her elder sister and requested that her name not be considered for the nominations hereafter. Despite this, Bhosle is the most frequent winner of this award to date, tying with Alka Yagnik. She was later given a Special Award for Rangeela in 1996, and the Filmfare Lifetime Achievement Award in 2001. Following is the list of her Filmfare Awards:

When S D Burman’s assistant Jaidev started giving music independently, he got Asha to sing some of his songs as well. They worked in Hum Dono (1961), Mujhe Jeene Do (1963), Do Boond Pani (1971) and other movies. In 1971, the pair released an LP of eight non-film devotional songs and ghazals called An Unforgettable Treat. Asha considered Jaidev a close friend who stood by her when she was struggling personally and professionally. Upon his death in 1987, she released a compilation album of lesser-known songs he had composed for her, called Suranjali.

They separated on 5 August 1972. It is not clear what made them part their ways. On being asked the reason for their parting, O. P. Nayyar once said, “I know astrology very well. I knew that one day I had to part with her. Something also happened that upset me, so I left her.” Nevertheless, he also said “…now that I am seventy-six, I can say that the most important person in my life was Asha Bhosle. She was the best person I ever met.”

Asha used to call R. D. Burman “Bubs”. She married him in 1980. Their partnership lasted until his death.

By the 1980s, Bhosle, although highly regarded for her abilities and versatility, had sometimes been stereotyped as a “cabaret singer” and a “pop crooner”. In 1981 she attempted a different genre by singing several ghazals for the Rekha-starrer Umrao Jaan, including “Dil Cheez Kya Hai”, “In Aankhon Ki Masti Ke”, “Yeh Kya Jagah Hai Doston” and “Justuju Jiski Thi”. The film’s music director Khayyam, had lowered her pitch by half a note. Bhosle herself expressed surprise that she could sing so differently. The ghazals won her the first National Film Award of her career. A few years later, she won another National Award for the song “Mera Kuchh Saamaan” from Ijaazat (1987).

Prolific Indian film composer Ilaiyaraaja began employing Asha’s vocals in the early 1980s, their earliest collaboration being for the film Moondram Pirai (1982) (remade in Hindi as Sadma in 1983). Their association continued, mostly through the latter half of the 1980s and early 1990s. Another notable song from this period is “Shenbagamae” for the movie Enga Ooru Pattukaran in 1987. In 2000, Asha sung the theme song for Kamal Haasan’s political film Hey Ram. The song, “Nee Partha Parvai” in Tamil and Janmon Ki Jwala in Hindi (or Aparna’s Theme), was a duet with singer Hariharan.

In a rare feat, noted lyricist Gulzar, music director R.D. Burman and Asha Bhosle came together in 1987 to create a double album, titled Dil Padosi Hai, which was released on 8 September 1987. In 1995, Asha underwent the gatha bandan (thread-tying) ceremony with Hindustani classical music maestro Ali Akbar Khan to learn a classical repertoire held within the Maihar gharana (stylistic school of Indian classical music), as handed down to Khan by his father Allauddin Khan (the guru of Ravi Shankar). Later, Asha and Ustad Ali Akbar Khan recorded eleven fixed compositions (or bandishes) in California for Legacy, a private album that earned them a Grammy Award nomination.

In 1995, 62-year-old Bhosle sang for actress Urmila Matondkar in the movie Rangeela. The soundtrack featured songs like “Tanha Tanha” and “Rangeela Re” sung by her, and composed by music director A. R. Rahman, who would go on to record several songs with her. During the 2000s, several of Bhosle’s numbers became chartbusters, including “Radha Kaise Na Jale” from Lagaan (2001), “Kambakht Ishq” from Pyaar Tune Kya Kiya (2001), “Yeh Lamha” from Filhaal (2002) and “Lucky Lips” from Lucky (2005). In October 2004, The Very Best of Asha Bhosle, The Queen of Bollywood, a compilation album of songs recorded by Bhosle for albums and Bollywood films that were released between 1966 and 2003, was released.

In 1996, Asha Bhosle sang Channeache Rati among several other songs in Rajendra Talak’s Konkani album Daryachya Deger with Suresh Wadkar.

In the 1990s, Asha experimented with remixed R.D. Burman songs. She was criticized by many, including Khayyam, for tampering with old melodies. Nevertheless, albums like Rahul And I became quite popular. In 1997, Asha did a private Indipop album Janam Samjha Karo with Lesle Lewis. The album was hugely popular and won her many awards including the 1997 MTV Award.

In the early 1990s, Asha sang with Boy George (“Bow Down Mister”) and Stephen Lauscombe. In 1997, she sang a love song with the boy band Code Red, at the age of 64. She also recorded the song “The Way you Dream” (One Giant Leap,) with Michael Stipe that was used in the English movie, Bulletproof Monk. The song was also released on the album 1 Giant Leap for 2002.

In 1997, the British band Cornershop paid tribute to Asha with their song “Brimful of Asha,” an international hit which was later remixed by Fatboy Slim. In 2001, the CD single of Nelly Furtado’s “I’m Like a Bird” included a “Nellie vs. Asha Remix” created by Digital Cutup Lounge.

British alternative rock band Cornershop released “Brimful of Asha” in 1997. The song dedicated to Asha Bhosle became an international hit single for the band and topping the UK Singles Chart in February 1998. A number of remixes have been released as well, notably by Norman Cook, also known as Fatboy Slim.

Asha had been once asked by director B. R. Ishara to compose music for one of his films, but she had politely declined. In 2002, she turned music composer with the album Aap Ki Asha, an eight-song music and video album. The lyrics were written by Majrooh Sultanpuri (his last lyrics). The album was released by Sachin Tendulkar on 21 May 2001 at a lavish party in Mumbai. The album received mixed reviews.

In the 1980s and 1990s, Asha went globe-trotting, staging concerts in Canada, Dubai, UK, US and many other countries. In October 2002, she did a concert with Sudesh Bhosle and others, in London, for “Help the Aged” to help raise funds for the elderly in India. In 2007 she toured the US, Canada, and West Indies in a tour called “The Incredibles”. In this tour, she was accompanied by singers Sonu Nigam, Kunal Ganjawala and Kailash Kher. This tour, originally scheduled for only 12 concerts, went on to run more than 20.

In 2003, British opera pop singer Sarah Brightman sampled her song “Dil Cheez Kya Hai” on her album Harem. It was used as the intro for her song “You Take My Breath Away”.

Asha has sung ghazals for many albums like Meraj-E-Ghazal, Aabshar-e-Ghazal and Kashish. In 2005, Asha released a self-titled album as a tribute to the four ghazal maestros – Mehdi Hassan, Ghulam Ali, Farida Khanum and Jagjit Singh. The album features eight of her favorite ghazals like Farida Khanum’s Aaj Jaane Ki Zid Na Karo, Ghulam Ali’s Chupke Chupke, Aawargi and Dil Mein Ek Lahar, Jagjit Singh’s Ahista Ahista and Mehdi Hassan’s Ranjish Hi Sahi, Rafta Rafta and Mujhe Tum Nazar Se. These classic ghazals were recreated with modern sounds by musician Pandit Somesh Mathur. The album was aimed at the younger generation, who, according to Asha, are “turned off” by the traditional sounds of tabla and sarangi.

In 2005, American string quartet Kronos Quartet re-recorded R D Burman compositions like “Chura Liya”, “Piya Tu” and “Mera Kuchh Saaman” among others and got Asha to sing them. Despite her age, she recorded three to four songs a day, leaving the quartet members stupefied. On 23 August 2005, You’ve Stolen My Heart: Songs from R.D. Burman’s Bollywood was released in US. The album was nominated for Grammy Awards 2006 in the category of “Best Contemporary World Music Album”. In the 1990s, a friend had introduced David Harrington of Kronos Quartet to the song “Aaj ki raat.” Harrington was mesmerised, and the song ended up on the album Kronos Caravan.

Also in 2005, The Black Eyed Peas sampled her songs “Ae Naujawan Sab Kuchh Yahan” (Apradh, 1972) and “Yeh Mera Dil Pyaar Ka Diwana” (Don, 1978) in their hit single “Don’t Phunk with My Heart”. In late 2006, Asha collaborated with Australian test cricket star, Brett Lee. The single, You’re the One for Me, debuted at number 4 on the charts and reached a peak position of number 2.

In 2006, she recorded an album Asha and Friends, singing duets, with film actors Sanjay Dutt and Urmila Matondkar and famous cricket player Brett Lee, with whom she sang, You’re the One for Me (Haan Main Tumhara Hoon). All these songs composed by Shamir Tandon were shot on video by journalist turned director S. Ramachandran.

In 2006 Asha recorded one song for the soundtrack of the Pakistani movie Mein Ek Din Laut Kay Aaaonga. She sang the song titled “Dil Key Taar Bajey”, with famous Pakistani pop singer Jawad Ahmed. It was aired as part of the film’s promotional campaign and became very popular, featuring on top music charts.

In 2013, Bhosle debuted in the film Mai in the title role, at the age of 79. Bhosle played the role of a 65-year-old mother who suffers from Alzheimer’s disease and is abandoned by her children. She received positive reviews for her acting as well from critics.

In 2014, she sang a song titled “Dil Lagane Ko Dil Jab” for the International Women’s Day special album, Women’s Day Special: Spreading Melodies Everywhere. It was composed by Shamir Tandon and penned by Saajan Agarwal.

In 2015, Asha Bhosle recorded a Sufi song, “Fariyad Sun Fakira” with co-singers Javed Ali and Pankaj Kumar.

Hemant Bhosle ‘s best known compositions were the Kishore-Asha duets such as “Aji Kaho Kya Haal Hai” from Anpadh picturised on Vijendra Ghatke and “Sarika” and “Salamat Raho Tum” from the same film “Anpadh” picturised on Ashok Kumar and Sarika. Hemant died of cancer in 2015.

In 2016, she recorded the album “82” with music director Mandar Agashe who decorated six of Suresh Bhat’s ghazals with his musical touch of pop, reggae, blues, and rock. The album was named after her age at the time of recording. About the album “8”, Bhosle said, “I had a long association with Suresh Bhat and have a lot of memories about him. With this album, I will relive those memories. I don’t need to tell you how powerful his words were and, with the album, that power can be experienced again. Mr. Bhat always wanted to record these ghazals in the pop and rock genres and it is good to see Mandar fulfilling that wish. I just wish Mr. Bhat was among us today.”

In May 2020, Bhosle launched her YouTube channel named Asha Bhosle Official.