Reeser portrayed Lizzy Grant in ten episodes of HBO's comedy-drama television series Entourage (2009–2010). First appearing in the show's sixth season, Lizzie is a junior agent working in the Miller Gold Agency's TV division under Andrew Klein, with whom she has an affair. Reeser played Phoebe Valentine, a goddess from Greek mythology in The CW's romantic comedy-drama series Valentine (2008–2009). In 2009, she portrayed lawyer Ashley Hastings in three episodes of TNT's legal drama series Raising the Bar. Reeser played Katie Andrews, Julie Benz's personal assistant in ABC's No Ordinary Family (2010–2011). The show centers on the Powells, a typical American family living in fictional Pacific Bay, California, whose members gain special powers after their plane crashes in the Amazon, Brazil. Reeser also had roles as Kylie Sinclair in Last Resort, as Dr. Gabrielle Asano in Hawaii Five-0 and as Abigail Bruce in Necessary Roughness. She had guest roles in several television shows, including It's Always Sunny In Philadelphia, Ghost Whisperer, Pushing Daisies, Human Target, Royal Pains, Jane by Design, and Hart of Dixie.
On May 9, 2009, Reeser married writer and director Jesse Warren in Ojai, California. The couple has two sons, one born in 2011 and the other in 2013. In November 2014, Reeser filed for divorce from Warren and requested joint physical and legal custody of their children.