Varlıer was born on 22 June 1977 in Ankara as the second daughter of ballerina Duygu Varlıer and economist Oktay Varlıer. She has an older sister named Aslı. While at the second year of high school, she went to New Jersey as part of a student exchange program. After graduating from high school, she studied musical theater at University of Hartford Hartt School. Later she participated in a mutual program between Harvard University and Moscow Art Theatre School and studied acting for 4 months in Moscow.

By the end of her studies, she was chosen by The Acting Company to work in a number of theater plays. Spring Awakening, Cher Molière, Man of La Mancha, Carnival, Guys and Dolls, Working, 42nd St., Henry IV, Battleship Potemkin and Virgin Trunk were among the musicals and plays in which she played a role. After September 11 attacks her visa was not renewed and she returned to Turkey. Following her return, she accompanied pianist Fahir Atakoğlu as a soloist. In 2004, she made her television debut with Kanal D’s series Karım ve Annem as Doctor Buket.

From January 2005 to June 2007 she portrayed the character of Pınar in Kanal D’s series Gümüş. Due to the series popularity in the Arab World, she became a familiar name in the households. On 15 February 2005, she had portrayed the character of Anita in Leonard Bernstein’s musical West Side Story, which was directed by Altan Günbay. In 2005, she portrayed Cinderella in an episode of Anlat İstanbul and also starred as Evrim in the movie O Şimdi Mahkum. In 2007, she portrayed Burcu in Turkmax’s TV film Havva Durumu. She appeared on stage on 26 June 2007 in Haldun Dormen’s musical Hisseli Harikalar Kumpanyası and played the character of Süheyla. On 13 August 2007, she appeared on stage again at Cemil Topuzlu Open-Air Theatre in the rock musical Rock Müzikaller. In 2008, she portrayed the character of Doctor Neşe in the second season of Show TV’s Kurtlar Vadisi Pusu; during the same period, from March to June 2008, she played as Gizem in ATV’s series Limon Ağacı. In August 2008, together with her family she found the WAMP management, organization and designing company.

In September 2008, she got her first leading role in TV as Sabiha Yılmaz in Star TV’s Son Bahar. She played opposite Erkan Petekkaya and the series finished in October 2008. From 2009 to 2010, she portrayed the character of Doctor Hayat in a number of episodes of Kanal D’s Geniş Aile. On 24 March 2010, she portrayed the character of an ill person with MS in Haldun Durmen’s play Sil Baştan.

On 6 May 2010, she started appearing on stage at Tiyatrokare as Roxy in the musical Leyla’nın Evi, based on Zülfü Livaneli’s novel of the same name and directed by Nedim Saban. For her performance in this musical; on 21 March 2011, she won the Best Comedy and Musical Actress award at the 15th Afife Theater Awards. On 25 April 2011, she won the Best Actress award at the 16th Sadri Alışık Award, followed by another award at the Vasfı Rıza Zobu Theater Awards ceremony. She later got a role in Engin Alkan’s musical Hekate’nin Şarkısı, which was organized by Istanbul City Theatres and first went on stage on 10 May 2010 at the 17th International Istanbul Theater Festival. She later recorded the song “Bir Zaman Hatası” for Emir Ersoy & Projecto Cubano’s compilation album Yaşama Bir Şans Ver, which was released by Soulfulworks Records on 6 August 2010.

From 2010 to 2011, she portrayed the character of Bahar in a number of episodes of Star TV’s Behzat Ç. Bir Ankara Polisiyesi. From January to April 2012, she played opposite Bülent Emin Yarar as Buket in Star TV’s series Kalbim 4 Mevsim. She later recorded the song “Sil Baştan” for Emir Ersoy & Projecto Cubano’s new compilation album Karnaval which was released by TMC on 12 May 2012. On 6 February 2013, her first studio album Elif was released by TMC. The album contained 8 songs, 5 of which were composed by herself.

From February to April 2014 she portrayed the character of Yıldız Gökçener in Kanal D’s Zeytin Tepesi. At the same year, she starred as Azra in Kerem Çakıroğlu’s movie Olur Olur!. The following year, he played the role of Doctor Emel in Ahmet Hoşsöyler’s Mavi Gece, a fantasy comedy movie in which she starred opposite Fırat Tanış. In 2015, she participated in a project for Hope Foundation for Children with Cancer and read Emre Kalcı’s poet “Anlama Hâli” on the song “Zamansız”, which was performed by Işın Karaca and included in the album Emre Kalcı Şiirleriyle… Aşkın On Hâli. It was released by DMC on 2 June 2015.

In 2015, she portrayed the character of Fosforlu Cevriye in the musical Fosforlu’nun Hikayesi, based on Suat Derviş’s novel Fosforlu Cevriye and directed by Serkan Üstüner. It was organized by Tuncer Cücenoğlu and went on stage at Tiyatrokare on 12 September 2015. For her performance, she won the Best Comedy and Musical Actress at the 21st Sadri Alışık Theater and Cinema Awards on 2 May 2016. From March to June 2016, she starred as Leyla Bozoğlu in ATV’s series Kehribar. At the same year, she appeared as Ayla Öker in one episode of Mordkommission Istanbul, which aried on Das Erste in Germany. On Valentine’s Day 2017, she released a music video for her song “Hoşçakal” on YouTube, which was written by herself. She later made a guest appearance in Kanal D’s Hayat Şarkısı as the character Mahsa. On 24 April 2017, she presented the 21st Afife Theater Awards at Haliç Congress Center.

Since November 2017, she has been starring in TRT 1’s series Kalk Gidelim as Nurcan Dal. She also appeared as Zühre, in the musical Tahir ile Zühre, which was directed by Onur Turan and written by Şefik Onat. The show first went on stage on 19 December 2017.