On 22 June 1974 she married banker André-Louis Auzière, with whom she had three children, Sébastien Auzière, an engineer, Dr. Laurence Auzière-Jourdan, a cardiologist, and Tiphaine Auzière, a lawyer. They resided in Truchtersheim until 1991, when they moved to Amiens. She, at the age of 40, met the 15-year-old Emmanuel Macron in La Providence High School in the year 1993, where she was a teacher and he was a student and a classmate of her daughter Laurence. She divorced Auzière in January 2006 and married Macron in October 2007.

In 1989, Brigitte Macron (then Auzière) unsuccessfully ran for a seat in the city council of Truchtersheim. It was the only time she ran for office.

In 2017, Brigitte Macron played an active role in her husband’s presidential campaign; a top adviser was quoted as saying that “her presence is essential for him”. During his campaign, Emmanuel Macron stated that upon his winning of the French presidency, his wife would “have the role that she always had with [him], she will not be hidden”.