In 1989, Bruce was introduced to his half-brother, Michael Buffer, when their birth father contacted Michael after seeing him on television. In the mid-1990s, Michael Buffer brought along his half-brother Bruce as his agent/manager. The pair have since worked together to form a company and grow their business via licensing and appearances. The name of the company is The Buffer Partnership.

Buffer is a world-rated poker player on the professional circuit. He has appeared on ESPN’s World Series of Poker Main Event show playing World Champion Chris Moneymaker at the televised table in 2007 and in 2005 made the Final Table of the World Poker Tour in the Season 3 Invitational at the Commerce Casino, where he placed 6th. He appeared on an MMA versus poker pro match during the sixth season of the NBC show Poker After Dark along with Strikeforce Fighter Dan Henderson and UFC Fighter Randy Couture. Buffer outlasted them as well as pros Erick Lindgren and Patrik Antonius to finish second, losing in heads-up play to Howard Lederer. At the World Series of Poker 2010 main event final table he was given the honor of starting the final table with the poker phrase “Shuffle up and deal!” As of September 2010, the Luxor Las Vegas has named their poker room after Bruce Buffer.

Buffer has appeared on some TV shows such as the Season 3 Episode 24 of Friends, “The One with the Ultimate Fighting Champion”. On the HBO series Entourage, he appeared in the episode entitled “Gotcha!”, announcing an exhibition fight for Chuck Liddell’s charity. On March 20, 2012, he was featured on the Comedy Central show Tosh.0. Buffer appeared as himself in the 2015 film Hot Tub Time Machine 2.

He also appeared as one of the fight fans alongside his brother Michael in the 2018 mystery comedy movie Holmes & Watson.

In October 2019 the gaming developer Relax Gaming released a new video slot with Buffer called “It’s Time”. The slot was developed with Buffer and the same company had earlier made a slot-game with Michael Buffer, Bruce´s older brother.