In 2017, Jones's team saw a significant turnover of starting players, and the results were not positive. After a 42–41 2OT victory over Georgia Tech in the season opener and a 42–7 win over Indiana State, the season started to shift downward. In the annual rivalry game against Florida, a last-second 26–20 loss on a game-winning Hail Mary from quarterback Feleipe Franks was a harbinger for the remaining conference games. In the next game, in a hard-fought win over Massachusetts, the Volunteers struggled until the end of the game. The next game, a 41–0 loss to #7 Georgia, was the worst shutout loss in Neyland Stadium history. The Volunteers lost the next conference game, a lethargic 15–9 performance against South Carolina, to start 0–3 in the SEC. The Vols' next game was 45–7 loss to #1 Alabama, the 11th straight victory for the longtime rivals. The Volunteers lost 29–26 to Kentucky in the next game for only the second time in the last 33 meetings between the two programs.
Jones was fired from his position as head coach on November 12, 2017. The decision came following a 50–17 loss to Missouri the previous day, which left Tennessee at a 4–6 record for the season and 0–6 in conference. The Vols' loss to the Tigers was their worst loss to an unranked opponent in the AP Poll era. He became the second coach in the SEC to be fired mid-season during 2017, after Jim McElwain had been fired from Florida two weeks prior. His replacement was interim head coach Brady Hoke, who had worked as the assistant head coach and defensive line coach during the 2017 season. Jeremy Pruitt was his permanent replacement.