Metropoulos is the executive chairman and chief executive officer of C. Dean Metropoulos & Company. The company was founded in 1993 and is based in Greenwich, Connecticut. As of 2011, C. Dean Metropoulos & Co. has been involved in over 72 acquisitions with over $12 billion in invested capital. The company jointly owns Hostess Brands along with Apollo Global Management.

Metropoulos lives in Palm Beach, Florida, with his wife Marianne, who in 2011, was President and Principal of Aegean Entertainment, a movie production company in Beverly Hills. They are parents of sons Evan and Daren. Daren purchased the Playboy Mansion for $100 million in 2016.

In September 2014 American entrepreneur Eugene Kashper, backed by TSG Consumer Partners, announced an agreement to acquire Pabst Brewing from C. Dean Metropoulos & Co for $700 million. The sale represented a gain of $550 million more than what the company paid for it in 2010. Bumble Bee Tuna is another brand owned by a company “bought and flipped” by the firm.

On July 7, 2015 there were rumors of a Hostess Brands IPO. Metropoulos has stated that there is no plan for an IPO. In July 2016, a Hostess IPO was announced.