In her senior season, Stanford started the season ranked No. 8 but moved up the polls with victories over No. 3 Rutgers (thanks to Wiggins hitting 2 free throws with 0.1 seconds left), and No. 10 Baylor. On December 22, Wiggins scored 21 points and led Stanford to a 73–69 overtime victory over 2007 NCAA champions Tennessee, Stanford's first win over Tennessee since 1996. On January 31, 2008, Wiggins scored 18 points in a win over USC at Maples Pavilion and passed Kate Starbird as the all-time leading scorer in Stanford women's basketball history. On March 2, 2008, she scored 24 points against Washington State to pass Lisa Leslie as the all-time leading scorer in Pac-10 women's basketball history. She was named the Pac-10 Player of The Year for the 2007–2008 season, the third time she has received the award. On March 24, 2008, she scored a career-high 44 points, pulled down 10 rebounds, and made 8 assists in an 88–54 win over UTEP as Stanford advanced to the Sweet Sixteen of the 2008 NCAA tournament; a week later, her 41 points propelled Stanford to its first Final Four appearance since 1997, where they would reach the final before losing to the University of Tennessee. In this performance Wiggins became the only player in NCAA women's basketball history to score 40-plus points in multiple NCAA Tournament games.
By the end of her career at Stanford Wiggins was a 4-time All American at Stanford. Only 7 people have been a four-time All-American in women's basketball. On April 4, 2008, Wiggins was awarded the Lowe's Senior CLASS Award. The following day Wiggins was awarded the Wade Trophy as the best women's college basketball player in NCAA Division I.
Wiggins was chosen as the third overall pick in the 2008 WNBA Draft by the Minnesota Lynx.
On May 18, 2008, she played in her first ever WNBA game. She scored 15 points, pulled down 4 rebounds, had 4 steals, and dished out 2 assists as the Minnesota Lynx beat the 2006 WNBA champions Detroit Shock 84–70.