Booth enjoyed an amateur career richly laced with records and accolades, being described as a Scottish golfing prodigy. Aged 12, she played with Sandy Lyle in the British Masters Pro-Am and at 14 she appeared in her first professional event, the Ladies Scottish Open, and finished 13th. She was rated the No. 1 junior in Europe after winning the European Junior Masters in 2007, the same year she lifted the Scottish Under-18 and Under-21 titles. In 2008, she became the youngest player to represent Great Britain & Ireland in the 76-year history of the Curtis Cup, facing the Americans in the 35th staging of that match at St Andrews. She also played at the Junior Ryder Cup in 2006 and 2008 and won the Daily Telegraph Finals in 2007 and 2008. In 2010, she finished 14th at LET Final Stage Qualifying School for 2010.

Booth made her professional debut on the Ladies European Tour at the Lalla Meryem Cup in Morocco. She won her first event in May 2012 at the Aberdeen Asset Management Ladies Scottish Open. She won her second event in June at the Deutsche Bank Ladies Swiss Open. Booth did not achieve her third win on the Ladies European tour until August 2019, when she won the Tipsports Czech Ladies Open.

She appeared nude in the 2013 ESPN The Magazine’s “Body Issue”.