In 2008 he played in all 13 games and recorded 67 tackles, including 13 tackles for loss and two sacks. Matthews compiled a career-high of nine tackles three times, against California, Stanford, and Oklahoma State. He finished as the team's sixth-leading tackler and third in terms of tackles for loss, with 13.0 for 44 yards. College Football News included him among their "120 Players To Know" and wrote that he is "fundamentally sound, he diagnoses plays well and has a knack for filling the proper lane, a couple of keys to being a successful inside linebacker." Matthews participated in the 2011 BCS National Championship Game, where Oregon lost to Auburn, 22–19. Matthews recorded a forced fumble against Heisman Trophy winner, Cam Newton, which led to a game-tying score late in the fourth quarter.