Le Bon was born on 4 March 1983 in Penboyr, Carmarthenshire, Wales, and first gained public attention when she supported Gruff Rhys (of the Super Furry Animals) on his 2007 solo UK tour. She appeared as a guest vocalist on Neon Neon’s 2008 single “I Lust U” from their album Stainless Style. Under her original name she provided backing vocals on Richard James’s debut solo album The Seven Sleepers Den in 2006. She also appeared on his second solo album, We Went Riding, from 2010.

Her first official release was a Welsh language EP, Edrych yn Llygaid Ceffyl Benthyg (“Looking in the Eyes of a Borrowed Horse”, similar to the English expression “to look a gift horse in the mouth”), on Peski Records in 2008. She also self-released the double A-side debut single “No One Can Drag Me Down” / “Disappear” (described by Gruff Rhys as “Bobbie Gentry and Nico fight over a Casio keyboard; melody wins!”) on her website. Le Bon worked alongside Gorky’s Zygotic Mynci’s Megan Childs, who contributed violin, and Super Furry Animals and Thrills collaborator John Thomas, who added pedal steel.

Her debut album, Me Oh My was released in 2009, followed by Cyrk and the Cyrk II EP in 2012.

In January 2013, Le Bon moved to Los Angeles to further her career in the US. Her third album, Mug Museum, was released November 2013. It was produced by Noah Georgeson and Josiah Steinbrick in Los Angeles, and featured Stephen Black (bass) and Huw Evans (guitar). She provided guest vocals on the track “Slow Train” from Kevin Morby’s debut album Harlem River.

In 2015, Le Bon collaborated with Tim Presley as DRINKS and released the album Hermits on Holiday in August 2015. DRINKS released their second album Hippo Lite in April 2018.

Le Bon released her fourth studio album, Crab Day, on 15 April 2016 on Drag City to generally favourable reviews. The album was produced by Josiah Steinbrick and Noah Georgeson, and again featured Stephen Black (bass) and Huw Evans (guitar), with Stella Mozgawa (drums). She noted how the collaboration with Presley had made her realise “that I make music because I love to, not because I have to”. On tour she was supported by Black and Evans and on occasion by Steinbrick and Josh Klinghoffer, a five-piece that also performs instrumental improvisations under the name BANANA.

In January 2017, Le Bon released the four-track EP Rock Pool via Drag City. It includes her version of the track “I Just Want to Be Good” which she wrote for Sweet Baboo’s 2015 album The Boombox Ballads. In the same month Leaving Records released Live by BANANA, recorded live during the band’s 2016 tour and Le Bon remixed Eleanor Friedberger’s ‘Are We Good?’

In 2018, Le Bon signed with Brooklyn based record label Mexican Summer (Ariel Pink, Jessica Pratt, Connan Mockasin). The same year, she joined John Cale on stage at The Barbican with the London Contemporary Orchestra.

Le Bon released her fifth studio album, Reward via Mexican Summer on 24 May 2019.