Green toured during 2010 and 2011 with an all-female backing band named "Scarlet Fever" (made up of Sharon Aguilar, Brittany Brooks, Theresa Flaminio, and Regina Zernay Roberts), performing for Taratata, the BBC, the Late Show with David Letterman, W's Symmetry Live Concert Series, Saturday Night Live, the Jimmy Kimmel Live! special show following the Academy Awards, and many other venues. Green also performed "Forget You", a sanitized version of his hit "Fuck You", with Gwyneth Paltrow and several puppets provided by The Jim Henson Company at the 53rd Annual Grammy Awards, on 13 February 2011. His performance was in part an homage to Elton John, who wore a very similar costume in a Muppet show performance in 1977. At the 2011 BRIT Awards two days later, Green was joined by British vocalist Joelle Bennett in another duet of "Fuck You". Shortly thereafter, it was announced that Green would join Rihanna and J. Cole on the North American leg of Rihanna's Loud Tour in the summer of 2011. However, he later dropped out of the tour, citing his busy work schedule, which included a commitment to judging The Voice, writing a new book, and recording a new album, as the reason for his withdrawal.
On 14 August 2011, Green appeared at WWE SummerSlam, performing "Forget You" and the event's theme, "Bright Lights Bigger City". He also performed at the 2011 Billboard Music Awards performance.
CeeLo re-released his album The Lady Killer as a Platinum Edition on 28 November 2011. The repackaged album contained the original 16 tracks, including remixed versions of "Bright Lights Bigger City" (feat. Wiz Khalifa) and "I Want You (Hold on to Love)", plus one extra track, written by Ross Golan, "Anyway". The new track served as the album's sixth overall single and first Platinum Edition single.
On 15 January 2011, Green both acted and performed on NBC's Saturday Night Live hosted by Gwyneth Paltrow, who, in November 2010, covered his song "Forget You" on an episode of Glee.
On 11 October 2011, Green guest-starred in the NBC series Parenthood in the episode "Tales From the Luncheonette".
On 14 August 2011, Green appeared at WWE SummerSlam and performed both "'Bright Lights Bigger City", the official theme song for the event, and his hit "Forget You". On 25 September 2011, Green appeared as himself in a live-action/voice appearance and as the voice of a hot tub in the American Dad! episode "Hot Water".
Managed by Primary Wave Entertainment, Green has endorsed various brands, including 7 Up, M&M's, and Duracell. Green owns part of the sake brand TY KU and the company has collaborated with him on a few business ventures, including a commercial promoting the brand, dubbed the "first national sake commercial" in the United States. In 2011, it was estimated by a New York Times reporter that Green earned some US$20 million dollars, predominantly from the endorsement deals, in that year alone.
On 16 June 2011, journalist Andrea Swensson of City Pages negatively reviewed one of Green's performances, writing that it "failed to measure up to the fun factor of his recorded material. Green spent most of the set stationed in front of a microphone at the center of the stage, barely moving an inch while he sang, and flanked by two forgettable back-up singers and a DJ that was all but hidden behind a giant LCD display". In response, the following day Green tweeted "I respect your criticism but be fair! People enjoyed last night! I'm guessing ur gay? And my masculinity offended u? well fuck U!" Green promptly received angered responses from some of his followers on Twitter, to which he replied "Apologies gay community! what was homophobic about that?" In a subsequent interview with magazine Us Weekly, Green stated that his comments were meant in good fun, adding that "I am not harboring any sort of negative feeling toward the gay community" and that "I am one of the most liberal artists that I think you will ever meet, and I pride myself on that."
On 31 December 2011, Green sang John Lennon's "Imagine" just prior to the ball drop for New Year's Eve at New York City's Times Square. In his rendition, Green replaced the line "and no religion, too" with the words "and all religions true". Many saw this as a substantial revision of the meaning behind Lennon's original lyrics. Shortly after the performance, Green responded via Twitter: "Yo I meant no disrespect by changing the lyric guys! I was trying to say a world where u could believe what u wanted that's all". Green deleted a series of tweets pertaining to this event shortly thereafter.