After releasing and promoting thirteen albums during the 1990s, Dion stated that she needed to settle down, and announced on her latest album All the Way... A Decade of Song, that she needed to take a step back from the spotlight and enjoy life. Angélil's diagnosis with esophageal cancer also prompted her to hiatus. While on break, she was unable to escape the spotlight. In 2000, the National Enquirer published a false story about the singer. Brandishing a picture of Dion and her husband, the magazine misquoted her, printing the headline, "Celine — 'I'm Pregnant With Twins!'" She later sued the magazine for more than $20 million. The editors of the Enquirer printed an apology and a full retraction to her in the next issue, and donated money to the American Cancer Society in honour of her and her husband. A year after the incident, after undergoing fertility treatments, she gave birth to a son, René-Charles Dion Angélil, on 25 January 2001, in Florida.
After the dissolution of Angélil's second marriage, he and Dion took a professional break and he spent the major part of the year in Las Vegas, while Dion was learning English and taking dance and singing lessons in Montreal. Upon his return, "he avoided being alone with me for too long a time", she said in her 2000 autobiography My Story, My Dream. Meanwhile, she kept a photo of Angélil under her pillow, writing, "Before I fell asleep, I slipped it under the pillow, out of fear that my mother, who always shared a room with me, would find it." She also wrote "Less and less could I hide from myself the fact that I was in love with Rene; I had all the symptoms," and "I was in love with a man I couldn't love, who didn't want me to love him, who didn't want to love me." Dion's mother, who traveled everywhere with the singer until she was 19, was initially wary of her daughter's growing infatuation with a much older and twice-divorced Angélil, but Dion was insistent, telling her mother "I'm not a minor. This is a free country. No one has the right to prevent me from loving whoever I want to."
In May 2000, Dion had two small operations at a fertility clinic in New York to improve her chances of conceiving, after deciding to use in-vitro fertilization because of years of failed attempts to conceive. Their first son, René-Charles Angélil, was born on 25 January 2001. Dion suffered a miscarriage in 2009. In May 2010, Angélil announced that Dion was 14 weeks pregnant with twins after a sixth treatment of in-vitro fertilization. On Saturday, 23 October 2010, at 11:11 and 11:12 am respectively, Dion gave birth to fraternal twins by Caesarean section at St. Mary's Medical Center in West Palm Beach, Florida, The twins were named Eddy, after Dion's favourite French songwriter, Eddy Marnay, who had also produced her first five albums, and Nelson, after former South African President Nelson Mandela. She appeared with her newborn sons on the cover of 9 December 2010 issue of the Canadian edition of Hello! magazine.