On 17 November 2010, she won her 142nd One Day International cap when she captained England against Sri Lanka to break the world record of 141 ODI appearances held by Australia's Karen Rolton. Edwards took a career best 4 for 30 in the game. Clare Connor, the England and Wales Cricket Board's Head of Women's Cricket, praised Edwards' achievement, calling her "a credit to women's cricket globally, a superb role model for girls who aspire to play for their country".
She scored her first Ashes century in England's one-off Test against Australia at Bankstown Oval on 22 January 2010, finishing unbeaten on 114 from an England first innings total of 207 all out.