Hoiles returned to the major leagues in 1991 when the Orioles traded away catcher Mickey Tettleton and gave Hoiles an opportunity to be their starting catcher. He made only one error in 89 games played as a catcher and ended the year with a league-leading .998 fielding percentage, becoming the fifth rookie catcher in major league baseball history to win a fielding title.
Hoiles was the Orioles' catcher on July 13, 1991, when four Orioles pitchers combined to pitch a no-hitter. In a game against the Kansas City Royals on April 9, 1998, Hoiles set a major league record for catchers by being involved in four double plays in one game.