Between 1995 and 2005, Ofili focused on a series of watercolors, each about 9½ by 6½ inches and produced in a single sitting. They predominantly feature heads of men and women, as well as some studies of flowers and birds. Ofili's paintings also make reference to blaxploitation films and gangsta rap, seeking to question racial and sexual stereotypes in a humorous way. In a series of faces that Ofili called Harems, each arrangement consists of one man with as many as four women on each side of him.
Ofili's work was featured in a museum in the 1995 exhibition Brilliant! New Art from London at the Walker Art Center. Significant solo exhibitions include the Arts Club of Chicago (2010), Kestnergesellschaft, Hanover (2006), the Studio Museum in Harlem, New York (2005), and Southampton City Art Gallery (1998). In 2010, Tate Britain presented the most extensive exhibition of his work to date. In 2014, The New Museum in New York presented the first, major solo show of Ofili's work in the U.S. titled Chris Ofili: Night and Day.