On July 23, prior to a game against the Detroit Tigers, the White Sox were set to wear throwback uniforms based on the design implemented by Bill Veeck during his second ownership of the White Sox. Sale was not pleased about the idea, as he felt the pullover jerseys were too baggy and interfered with his pitching mechanics, and this prompted him to use scissors to tear up the throwback uniforms that had been laid out in the clubhouse while the rest of the team was on the field for practice. Shortly after, the White Sox sent Sale home and scratched him from his start that day, and the White Sox took the field in their 1982-86 throwbacks instead. The next day, on July 24, the White Sox suspended Sale for five days. Sale made 32 starts in 2016, finishing with a 17–10 record, a 3.34 ERA, and 233 strikeouts, in 226.2 innings pitched. He also pitched 6 complete games and hit 17 batsmen with pitches, in which both categories led the MLB.
On December 6, 2016, the White Sox traded Sale to the Boston Red Sox for Yoan Moncada, Michael Kopech, Luis Alexander Basabe, and Victor Diaz. Upon joining Boston, Sale switched his uniform number from 49 to 41 out of respect for Tim Wakefield.
Notes: Through 2016 season. Per Baseball-Reference.com.