In 1960, Smither and two friends entered and won a folk “Battle of the Bands” at the New Orleans Saenger Theatre. Two years later, Smither graduated from Benjamin Franklin High School in New Orleans and went on to attend the University of the Americas in Mexico City planning to study anthropology. It was there that a friend played Smither the Lightnin’ Hopkins’ record “Blues in My Bottle”. After one year in Mexico, Smither returned to New Orleans where he attended Tulane for one year and discovered Mississippi John Hurt’s music through the Blues at Newport 1963 album on Vanguard Records. Hurt and Hopkins would become cornerstone influences on Smither’s own music.

In 1964, Smither flew to New York City two days prior to boarding the SS United States for the five-day transatlantic voyage to Paris for his Junior Year Abroad program. While in New York, he stopped at The Gaslight Cafe to see his hero, Mississippi John Hurt. Once in Paris, Smither often spent time playing his guitar instead of attending classes.

Smither returned to New Orleans in 1965. With a few clothes and his guitar, he soon took off for Florida to meet another musical hero, Eric von Schmidt. Smither arrived uninvited at von Schmidt’s door; Von Schmidt welcomed Smither in, and upon listening to him play, advised him to go north to seek a place in the burgeoning folk scene in New York City or Cambridge, Massachusetts. Smither followed this advice, and arrived at Club 47 in Harvard Square several weeks later only to find von Schmidt performing. Von Schmidt invited Smither on stage to play three songs.

Smither soon began writing and performing his own songs. He achieved some local notice and by 1967 was featured on the cover of The Broadside of Boston magazine. In 1968, music photographer David Gahr’s book, The Face of Folk Music featured Smither’s picture.

By 1969, after living in several places around Cambridge, Smither moved to Garfield Street in Cambridge and often visited Dick Waterman’s house where Fred McDowell, Son House and other blues musicians were known to congregate. It was there that Smither first performed his song “Love You Like a Man” for Waterman’s friend, Bonnie Raitt. That summer, he appeared at the Philadelphia Folk Festival for the first time.

In 1970, he released his first album I’m a Stranger Too! on Poppy Records, followed by Don’t It Drag On the next year. He recorded a follow up, Honeysuckle Dog, in 1973 for United Artists Records but Smither was dropped from the label and the album went unreleased until 2004, when it was issued by Tomato Records. Despite no longer having a recording contract Smither continued to tour and became a fixture in New England’s folk clubs.

In 1972, a longstanding working relationship with Bonnie Raitt took shape as Raitt’s cover of “Love Me Like a Man” appeared on her second album Give It Up. Raitt has since made it a signature song of her live performances, and the song has been included on several of her live albums and collections. She has openly expressed admiration for Smither’s songwriting and guitar playing, once calling Smither “my Eric Clapton.” In 1973, Raitt covered Smither’s song “I Feel the Same” on her Takin’ My Time album.

Smither began to re-emerge as a performer in the late 1970s, and gained a few press notices. In 1979, he was featured in Eric von Schmidt and Jim Rooney’s book, Baby Let Me Follow You Down, and the next year in the UK’s Melody Maker magazine.

In 1984, Smither’s belated third album, It Ain’t Easy was released on Adelphi Records, which the Boston Phoenix acoustic music critic Jon Herman called “the naked and sophisticated blues album that Eric von Schmidt, Rolf Cahn, Spider John Koerner, and other white revivalists groped for more than 20 years ago, at the dawn of the folk revival.”

He recorded his next album, Another Way to Find You, in front of a live audience at Soundtrack Studio in Boston and in 1991 released it on Flying Fish Records. Later that year he received a Boston Music Award. Two years later, he was invited to compose music for a documentary on Southern folk artists and met Southern folk artist Mose T.

In 1993, Smither recorded and released his fifth album, Happier Blue (Flying Fish), which earned Smither a National American Independent Record Distributors NAIRD award. Another two years later, he released Up on the Lowdown (Hightone Records), which was recorded at the Hit Shack in Austin, Texas. This was the first of three records produced by Stephen Bruton. Also that year, the Chris Smither Songbook I was published.

In 1996 he began recording live concerts in the US and Ireland for what would later become a live CD. The next year, he released his seventh album, Small Revelations (Hightone), and filmed an instructional guitar video for Happy Traum’s Homespun Tapes in Woodstock, New York.

In 1997 Smither’s music was used exclusively on the entire score of the short film, The Ride, directed by John Flanders and produced by Flanders’s company, RoughPine Productions. Flanders plays a folk-singer in the film who is largely influenced by Smither. The Ride won the Audience Best Film Award at the 2002 Moscow Film Festival.

1998 was a year of small breakthroughs and the start of a fertile songwriting and recording period for Smither. HighTone reissued Another Way to Find You and Happier Blue and Jorma Kaukonen invited Smither to teach at his Fur Peace Ranch in Ohio. In addition, Smither toured with Dave Alvin, Ramblin’ Jack Elliott and Tom Russell as Hightone’s Monsters of Folk tour, and Emmylou Harris recorded his song “Slow Surprise”, for the Horse Whisperer soundtrack.

In 1999, Smither released Drive You Home Again (HighTone). Also in 1999 he went to New Zealand and played at the Sweetwaters Music Festival.

In 2000, he released, Live As I’ll Ever Be (HighTone), comprising the live recordings made two years earlier. His song “No Love Today” was featured in the Bravo network program Tale Lights. The following year, songwriter Peter Case invited Smither to be part of a Mississippi John Hurt tribute record for which he contributed the opening track, “Frankie and Albert”.

In 2003, Train Home was released on Hightone. In 2004, jazz singer Diana Krall covered “Love Me Like A Man” on her CD, The Girl in the Other Room.

In September 2006, Smither released Leave the Light On (Signature Sounds Recordings) produced by David ‘Goody’ Goodrich. His song, “Diplomacy,” from the CD was named No. 42 on Rolling Stone Magazine’s list of 100 Best Songs of the Year 2006. Smither was also named as 2007’s Outstanding Folk Act by the Boston Music Awards. That year he also contributed an essay entitled “Become a Parent” to the book Sixty Things to Do When You Turn Sixty (Ronnie Sellers Productions). And he narrated a two-CD audio book recording of Will Rogers’ Greatest Hits (Logofon Recordings).

Smither released a 78-minute live concert DVD, One More Night, (Signature Sounds) in February 2008.

In May 2009, Smither’s short story “Leroy Purcell” was published in Amplified (Melville House Publishing), a collection of fiction by fifteen prominent performing songwriters.

Smither’s thirteenth CD Time Stands Still was released on September 29, 2009, on Signature Sounds. On this, his most stripped down recording in some time, Smither worked with just two accompanists after the same trio had played a rare band performance – a non-solo setup required to play a Netherlands festival. About the recording Smither says, “We’re the only three guys on this record, and most of the songs only have three parts going on. We had a freewheeling feeling at that festival gig, and we managed to make a lot of that same feeling happen in this record.”

On February 8, 2011, Smither was profiled in The New York Times “Frequent Flier” column, entitled, “The Drawbacks of a Modest Celebrity,” in which he recounts anecdotes from his four decades as a traveling musician.

Always wanting to treat his fans well, in 2011 Smither put out two fan projects: a collection of live tracks from newly discovered concert recordings from the 1980s–1990s titled Lost and Found and the rollicking EP, What I Learned in School, on which Smither covered six classic rock and roll songs.

In 2014, Chris Smither marked fifty years of songwriting with the release of Still on the Levee – a double-CD retrospective. Recorded in New Orleans at the Music Shed, this career-spanning project features fresh new takes on 24 iconic songs from his vast career – including “Devil Got Your Man,” the first song he penned, on up to several of his most recent originals. The band included Billy Conway on drums.

Coming out at the same time as Still on the Levee, the book Chris Smither Lyrics 1966–2012 features his complete set of lyrics complemented by select images and performance memorabilia from his decades-long career. To commemorate his career to-date, on September 30, 2014, Signature Sounds released an all-star tribute record (Link of Chain: A Songwriters’ Tribute to Chris Smither) including a list of artists offering their takes on some Smither favorites including Josh Ritter, Bonnie Raitt, Loudon Wainwright III, Dave Alvin, Peter Case, Tim O’Brien, and Patty Larkin.

The 2018 release Call Me Lucky also included Conway on drums.