Chrissy Costanza was born on August 23, 1995, in New Jersey into an Italian American family. She has a brother named Michael Costanza. Growing up, it was one of her dreams to become a musician. She met current band members Dan Gow and Will Ferri through a mutual friend.

Chrissy Costanza was introduced to Dan Gow and Will Ferri through a mutual friend in 2011, joining their band. Against The Current soon started to write original songs, whose lyrics were mostly written by Chrissy. They also started to post covers of popular songs on YouTube. Against The Current released their first single “Thinking” in 2012. Meanwhile, Chrissy made a self-titled YouTube channel and started posting beauty videos. During the summer of 2013, Against the Current went on tour with Alex Goot.

Against the Current released their first EP, Infinity in 2014. On June 6, Costanza made an appearance in Access Hollywood. In February 2015, Against The Current released their second EP, Gravity. At the end of April 2015, Against The Current had signed a record deal with Fueled by Ramen. At the end of August, they embarked on their first world tour, the “Gravity World Tour”. Against The Current released their debut album In Our Bones on May 20, 2016. In May, following the release of their debut album, Chrissy performed live with Alex Goot on his tour on several occasions. While they were in the UK, Against The Current was asked to play a last minute set at the Download Festival. Kerrang!, a UK-based magazine devoted to rock music, says that the band are “writing their future”, and described Chrissy as “Their Fearless Frontwoman”. At the end of June, Rock Sound announced that Chrissy would receive her own column in their monthly magazine to talk about Against The Current’s debut album, writing her own lyrics for the band, touring, and giving advice on how aspiring bands can be successful.

Against the Current recorded the song “Legends Never Die” for the video game League of Legends, as a tie-in for the 2017 League of Legends World Championship. Against the Current released their second studio album, Past Lives in 2018. Against The Current returned to Reading and Leeds Festival in August after which the band made their first appearances at Lollapalooza 2019 and Pentaport Rock Festival . Chrissy collaborated with Cailin Russo on the song “Phoenix” for the 2019 League of Legends World Championship, which she then performed at the finals in Paris, France and again on New Years Eve at Bilibili New Years Eve Concert in Beijing, China. Chrissy performed the songs “Each Goal” and “Hero too” as the character Kyoka Jiro in the anime series My Hero Academia.

In July 2020, it was announced that Chrissy Costanza would be the host of the show Guest House on streaming media channel VENN.