On March 31, 2019, Yelich became the sixth player in MLB history to hit a home run in each of his team's first four games.
On July 1, 2019, Yelich became the first player in Brewers franchise history to reach 30 home runs before the All-Star Break, beating former Brewer Prince Fielder's record of 29 home runs. Yelich was selected to participate in the Home Run Derby but had to withdraw due to a back injury. He was replaced by Matt Chapman in the Home Run Derby. On September 10, 2019, Yelich hit a foul ball off his kneecap and left the game. Shortly thereafter, it was revealed that his right kneecap was fractured, which prematurely ended his 2019 season.
In 2019, Yelich won his second National League batting title. He batted .329/.429 (leading the NL)/.671 (leading the major leagues) with a 1.100 OPS (leading the majors), 44 home runs (4th in the NL), 11.1 at bats per home runs (leading the league), a .342 ISO (leading the NL), 30 stolen bases (3rd), a 93.75 stolen base percentage (3rd), and 97 RBIs in 130 games. He had the highest Hard Contact Percentage of all National League batters, at 50.8%. Yelich was the first National League player to lead the league in batting average and slugging percentage in consecutive seasons since Rogers Hornsby, who did so from 1920 to 1925. He won the NL Hank Aaron Award for the second year in a row and finished second in NL MVP voting.
Yelich appeared in an episode of Magnum P.I. that aired on March 4, 2019. Yelich once invited Cleveland Browns quarterback and 2017 Heisman Trophy winner Baker Mayfield to Brewers batting practice.