When not on the field, Pearce studied towards a degree in Special Education, which she completed in 1996. She also worked as a volunteer basketball and soccer coach when completing her student teaching with Monmouth. As a tribute to her achievements and for the worldwide fame she brought to her alma mater, the university awarded her with an honorary degree in Public Service in 2005. Furthermore, the university inducted her into the Monmouth University Hall of Fame in 2007 and honored her 2008 Olympic accomplishments by declaring October 5, 2008 as Christie Rampone Day.

After college, Pearce played for Central Jersey Splash and New Jersey Lady Stallions, in 1997 and 1998 respectively, of the W-League.

After training with the United States women’s national soccer team during her senior year at Monmouth, she switched to playing as a defender. Pearce’s first game was February 28, 1997 versus Australia. She tallied her first national team goal on May 2, 1997, in a match versus South Korea. Pearce started 16/18 games in her first season and finished with two goals and three assists. The following year, Pearce helped her team to its first undefeated season and led the United States to gold in the 1998 Goodwill Games by starting in both matches.

Pearce played 2540 minutes with the national team in 2000, including five games at the 2000 Summer Olympics in Sydney. The team finished with the Silver medal. In 2001, Pearce tore her anterior cruciate ligament and missed a majority of the limited national team season. Pearce was back with the team for two training camps in 2002, but focused on recovering from her surgery. In 2003, she started in 15/17 national team games and all four World Cup matches to lead her team to the Bronze medal.

In 2001, she was selected as a member of New York Power, a professional soccer team in Women’s United Soccer Association. In the first year, Christie played every minute of the first 18 games until tearing her anterior cruciate ligament, sidelining her for the rest of the season. In 2002, Christie bounced back to play in 1699 minutes over 19 games, and another 18 games in 2003 in addition to her national team duties. Shortly after concluding its third season, the WUSA suspended all operations. In anticipation of an eventual relaunch, WUSA preserved its rights in the team names, logos and similar properties.

In the 2004 Athens Olympics, she helped the United States win gold after defeating Brazil in what would be the final Olympic Games for a few of her senior teammates: Mia Hamm, Brandi Chastain and Julie Foudy. It was in this same year that Pearce would become the fifth most capped defender in United States history.

Pearce returned to the team in 2006, after taking off the 2005 season to have her first child. In 2006, Christie returned to the team just 112 days after giving birth for China’s Four Nations Tournament. 2007 brought Pearce’s busiest year to date, starting in all 20 games in which she played and she became the most capped defender and second-most capped played on the 2007 FIFA Women’s World Cup team. She started in all six matches of the World Cup.

The next attempt at women’s professional soccer in the United States kicked off in 2008 under the name of Women’s Professional Soccer. On September 16, 2008, the initial WPS player allocation was conducted and Pearce was chosen as captain for New Jersey’s Sky Blue FC with fellow US Women’s National Team players Heather O’Reilly and Natasha Kai.

In 2008, Pearce was named captain of the Women’s National Team and led the United States to the Gold medal once again, earning her 200th National Team cap at the 2008 Summer Olympics. With the retirement of teammate Kristine Lilly in 2010, she became the most capped active player in the world.

In its inaugural season, Pearce and Sky Blue FC struggled, including the suspension of their first head coach Ian Sawyers and the resignation of his successor, Kelly Lindsey. In July 2009, the Sky Blue organization announced that Pearce would serve as the caretaker coach, in addition to her playing duties, for the remainder of the WPS season. After taking on the position as head coach, the third in one season for Sky Blue FC, Pearce took her team on to win the 2009 Women’s Professional Soccer Playoffs. It was later revealed she was almost three months pregnant with her second child at the time of the match. One week later, she was named WPS Sportswoman of the Year.

In July 2011, Pearce revealed she had Lyme disease. Pearce is currently engaged to Racing Louisville FC head coach Christy Holly

In 2012 London Olympics, Pearce captained the USA team to a 2–1 gold medal win over Japan in the final; playing all 570 minutes in 6 matches and was a key free kick taker throughout the tournament. Pearce also saved a shot off the line from Japan in the Olympic final. The USA team won all six matches it played at the 2012 London Olympics, including 3 shutouts.

In 2012, Jersey Mike’s Subs appointed Jersey Shore native Pearce as its first spokesperson in its 56-year history. She and her ex-husband have since become franchisees of the chain, opening two locations in Toms River, New Jersey in early 2017.

On January 11, 2013 Pearce was one of three members from the United States women’s national team that was allocated to the new NWSL club Sky Blue FC, along with Jillian Loyden and Kelley O’Hara.

On July 5, 2015, she became the oldest woman to play in a FIFA Women’s World Cup final, and in any tournament game, at age 40 years, 11 days, when she entered the final against Japan during the 86th minute. In 1999 she played against Korea DPR in the group stage, and in 2015 she played against Nigeria in the group stage, and in the final against Japan.

Pearce was featured along with her national teammates in EA Sports’ FIFA video game series in FIFA 16, the first time women players were included in the game. In September 2015, she was ranked by EA Sports as the number 8 women’s player in the game.

Pearce has two daughters with her ex-husband Chris Rampone: Rylie (born 2005) and Reece (born 2010). She and Rampone divorced in 2017. Though married to Chris in 2001, Pearce did not use the name “Rampone” on her jersey until 2004.