Christy Walton

Non-profit organizations in which Walton is actively serving include the national association of trustees and staff, corporate giving officers, and individual donors of The Philanthropy Roundtable. The San Diego Natural History Museum, where she is a board member, as well as the San Diego Zoological Society and the Mingei International Museum are also institutions to which she makes donations. In 2006, Walton donated her own old Victorian home which was built in 1896 for former National City, California postmaster Oliver Noyes and is of historical significance, to the International Community Foundation - Center for Cross-Border Philanthropy. Since her donation, she has endowed $4 million towards the edifice's preservation.

Additionally, she supports her family's own charitable foundation, the Walton Family Charitable Support Foundation, which prioritizes education and benefits institutions of higher education such as the Sam M. Walton College of Business at the University of Arkansas, and several other colleges, community trusts, universities and foundations. In 2007, her family's foundation donated as much as $1.6 billion.

Variety reported on March 2, 2009 that Christy Walton had set up a production company called Tenaja Productions to finance a film adaptation of Bless Me, Ultima, a popular Chicano coming of age novel. Filming wrapped in Santa Fe, New Mexico in late 2010. The film premiered at the Plaza Theatre in El Paso, Texas on September 17, 2012, and received a general release in February 2013.

Walton backed The Lincoln Project, an anti-Trump super-PAC, which ran ads in battleground states. She donated $20,000 to The Lincoln Project in January 2020 and a further $10,000 in May 2020.