Sampson appeared in Season 3 of Supernatural as the character Lisa Braedon, in the episode "The Kids Are Alright" in 2007. She reprised the role for the episode "Dream a Little Dream of Me" after showrunner Eric Kripke could not get the rights to use the character Jason Voorhees, the villain of the Friday the 13th horror film series. Sampson's character was brought back in the fifth-season episodes "99 Problems" and "Swan Song" as setup to season six, in which she appeared in 11 episodes. Her final appearance was in the episode "Let It Bleed" (season 6, episode 21).