In 2011, Wilson was 16–7 with a 2.94 ERA (seventh in the AL). He led the league in games started (34), and was fourth in wins, fifth in win-loss percentage (.696), and sixth in strikeouts (206; sixth-most in Rangers history).
On December 8, 2011 Wilson agreed to a five-year, $77.5 million deal with the Los Angeles Angels of Anaheim. This deal came only hours after Albert Pujols signed a record breaking ten-year, $250 million deal with Anaheim. The contract became official on December 10.