In 2016, Wineland was listed as one of Seventeen magazine’s 17 Power Teens. She was a Fox Teen Choice Award Honoree in 2015 and received the Gloria Barron Prize for Young Heroes and Los Angeles Business Journal’s Small Nonprofit of the Year Award in 2014.

On August 7, 2017, after not uploading any videos onto her YouTube channel for over a year, Wineland made a return to YouTube with a new account under her real name. Her first uploaded video titled, “I stopped doing the Clarity Project because I got screwed over,” revealed that The Clairity Project was not operated by her, but by a video editing company, and she had little to no control or input over the editing of her videos apart from its filming and creation. She revealed that after taking a break from creating videos for some months due to declining health, the company refused to allow her to log into any accounts relating to The Clairity Project. Due to no formal contracts over ownership of the project being in place, the company continued to profit from The Clairity Project, which essentially had her namesake, without Wineland ever having any control or seeing any profits. Wineland stated she did not have the energy or the money to take the case to court, however. Wineland continued to operate her very own YouTube channel where she uploaded personal vlogs regarding her personal feelings and thoughts, cystic fibrosis, her life expectancy and a lung transplant. She uploaded nine videos prior to her death.

On August 26, 2018, Wineland underwent a double lung transplant. Shortly after the surgery, Wineland had a stroke due to a blood clot which “cut off blood flow to the right side of her brain.” Wineland died, aged 21, on September 2, 2018, at the UC San Diego Thornton Pavilion.

The 2019 film Five Feet Apart was inspired by and dedicated to Wineland, who had served as a consultant on the film.

YouTube Originals released a documentary about Claire Wineland. “Claire” is directed and produced by Academy Award winner Nicholas Reed (“The Lady in Number 6”) and Ryan Azevedo (“Unpinned”) and produced by Paul Foley (“Unpinned”). This documentary was released on the first anniversary of Wineland’s death on September 2, 2019.